由于一些证据表明雌激素可能参与肺癌的发生,据推测,植物雌激素的摄入量,分子结构与哺乳动物雌激素相似,可能与肺癌的发展有关。
目的是前瞻性评估植物雌激素暴露与不吸烟女性患肺癌风险之间的关系。
我们在一项基于人群的女性前瞻性队列研究中进行了一项巢式病例对照研究。在平均15.6年的随访后,在从不吸烟的女性中发现了总共478例肺癌事件病例及其个体匹配的对照。通过反复的饮食调查和尿液生物标志物来评估植物雌激素的习惯性摄入和内部暴露。分别。在条件逻辑回归模型中估计肺癌的OR和95%CI。
调整潜在的混杂因素后,在不吸烟的女性中,适量摄入异黄酮与肺癌风险呈负相关,用OR表示第二个四分位数与摄入的最低四分位数为0.52(95%CI:0.35,0.76)。进一步增加摄入量并没有带来额外的好处,第三和第四个四分位数的OR(95%CI)为0.53(0.36,0.78)和0.47(0.31,0.72),分别(P-总体<0.001和P-非线性=0.006)。当通过尿生物标志物评估暴露于异黄酮类时,观察到类似的关联。第二次的OR(95%CI),第三,与尿异黄酮排泄量最低的四分位数相比,第四四分位数为0.57(0.39,0.83),0.64(0.44,0.92),和0.60(0.41,0.86),分别。逆关联达到了第二个四分位数以外的平台,P-总体=0.04,P-非线性=0.15。肠道微生物来源的木脂素代谢产物的尿液排泄与肺癌风险无关。
这项研究表明,在不吸烟的女性中,适度增加富含异黄酮的食物的摄入量与降低患肺癌的风险有关。
Since several lines of evidence suggest that estrogens may be involved in lung carcinogenesis, it has been hypothesized that intake of phytoestrogens, similar in molecular structure to mammalian estrogens, may be associated with lung cancer development.
The aim was to prospectively evaluate the association between phytoestrogen exposure and lung cancer risk in never-smoking women.
We conducted a nested
case-control study within a population-based prospective cohort study of women. A total of 478 incident lung cancer cases and their individually matched controls were identified among never-smoking women after a mean follow-up of 15.6 years. Habitual intake of and internal exposure to phytoestrogens were assessed by repeated dietary surveys and urinary biomarkers, respectively. ORs and 95% CIs for lung cancer were estimated in conditional logistic regression models.
After adjustment for potential confounders, a moderate intake of dietary isoflavones was inversely associated with lung cancer risk in never-smoking women, with the OR for the second quartile vs. the lowest quartile of intake being 0.52 (95% CI: 0.35, 0.76). Further increasing intake did not convey additional benefits, with ORs (95% CI) for the third and fourth quartiles of 0.53 (0.36, 0.78) and 0.47 (0.31, 0.72), respectively (P-overall < 0.001 and P-nonlinearity = 0.006). A similar association was seen when exposure to isoflavones was assessed by urinary biomarkers. ORs (95% CI) for the second, third, and fourth quartiles compared with the lowest quartile of urinary
isoflavone excretion were 0.57 (0.39, 0.83), 0.64 (0.44, 0.92), and 0.60 (0.41, 0.86), respectively. The inverse association reached a plateau beyond the second quartile, with P-overall = 0.04 and P-nonlinearity = 0.15. Urinary excretion of gut-microbiota-derived metabolites of lignans was not related to lung cancer risk.
This study suggests that moderately increasing intake of
isoflavone-rich foods is associated with lower risk of lung cancer in never-smoking women.