背景:年龄相关性听力损失(ARHL)是困扰老年人的主要疾病之一,对社会产生重大负面影响,经济,和健康。然而,由于缺乏全面的试验,目前尚无ARHL的适当治疗方法.
目的:这篇综述的目的是系统评估和分析病理分类的最新统计数据,危险因素,治疗策略,和ARHL的候选药物,包括中医(TCM),为ARHL的预防和治疗提供潜在的新方法。
方法:与ARHL相关的文献在诸如PubMed,WOS,中国国家知识基础设施(CNKI),和万方从建立数据库到简,2023年。病理学,因果因素,病理生理机制,治疗策略,并提取ARHL的候选药物并汇集用于合成。
结果:关于ARHL病因学的许多假设都基于遗传和环境因素。目前对ARHL病理的研究大多集中在氧化损伤,线粒体功能障碍,炎症,耳蜗血流,离子稳态,等。在中医,属于肾脏的草药,肺,和肝经络表现出良好的听力保护。属于肾经的七种草药,9属于肺经,本综述最终检索到4个属于肝经的,如何首乌。,人参C.A.Mey,和葛根(威尔德。)Ohwi。它们的活性化合物,2,3,4',5-四羟基二苯乙烯-2-O-D-葡萄糖苷,人参皂苷Rb1和葛根素,可以作为其抗ARHL功效的分子物质,并显示抗氧化,神经保护,抗炎,抗凋亡,或线粒体保护作用。
结论:抗氧化剂,线粒体功能的调节剂,抗炎药,血管扩张剂,K+通道开启器,Ca2+通道阻断剂,JNK抑制剂,和神经生长因子/神经营养因子都有助于听力保护,和草药是潜在的抗ARHL药物的重要来源。
BACKGROUND: Age-related hearing loss (ARHL) is one of the main illnesses afflicting the aged population and has a significant negative impact on society, economy, and health. However, there is presently no appropriate therapeutic treatment of ARHL due to the absence of comprehensive trials.
OBJECTIVE: The goal of this
review is to systematically evaluate and analyze recent statistics on the pathologic classifications, risk factors, treatment strategies, and drug candidates of ARHL, including that from traditional Chinese medicine (TCM), to provide potential new approaches for preventing and treating ARHL.
METHODS: Literature related to ARHL was conducted in databases such as PubMed, WOS, China National Knowledge Infrastructure (CNKI), and Wanfang from the establishment of the database to Jan, 2023. The pathology, causal factor, pathophysiological mechanism, treatment strategy, and the drug candidate of ARHL were extracted and pooled for synthesis.
RESULTS: Many hypotheses about the etiology of ARHL are based on genetic and environmental elements. Most of the current research on the pathology of ARHL focuses on oxidative damage, mitochondrial dysfunction, inflammation, cochlear blood flow, ion homeostasis, etc. In TCM, herbs belonging to the kidney, lung, and liver meridians exhibit good hearing protection. Seven herbs belonging to the kidney meridian, 9 belonging to the lung meridian, and 4 belonging to the liver meridian were ultimately retrieved in this
review, such as Polygonum multiflorum Thunb., Panax ginseng C.A. Mey, and Pueraria lobata (Willd.) Ohwi. Their active compounds, 2,3,4\',5-Tetrahydroxystilbene-2-O-D-glucoside, ginsenoside Rb1, and puerarin, may act as the molecular substance for their anti-ARHL efficacy, and show anti-oxidative, neuroprotective, anti-inflammatory, anti-apoptotic, or mitochondrial protective effects.
CONCLUSIONS: Anti-oxidants, modulators of mitochondrial function, anti-inflammation agents, vasodilators, K+ channel openers, Ca2+ channel blockers, JNK inhibitors, and nerve growth factors/neurotrophic factors all contribute to hearing protection, and herbs are an important source of potential anti-ARHL drugs.