国家的心脏,肺,和血液研究所和心血管医学研究和教育基金举办了关于肺血管疾病组学数据应用的研讨会,预防,和肺血管疾病的治疗。肺血管疾病专家,组学,和数据分析会议,以确定知识差距,并根据国家心脏为肺血管疾病的未来研究重点制定思路,肺,和血液研究所的战略愿景目标。该小组确定了开发对多组数据集的分析方法的机会,为了确定肺血管疾病病理生物学中的分子途径,并将新的表型与有意义的临床结果联系起来。委员会建议支持跨学科研究团队开发和验证分析方法,协调生物样本和数据的国家努力,一个由临床前研究人员组成的联盟,以加快目标评估和药物开发,临床试验中分子生物标志物的纵向评估,和一个专责小组,以制定针对肺血管疾病的主要临床试验方案。
The National Heart, Lung, and Blood Institute and the Cardiovascular Medical Research and Education Fund held a workshop on the application of pulmonary vascular disease omics data to the understanding, prevention, and treatment of pulmonary vascular disease. Experts in pulmonary vascular disease, omics, and data analytics met to identify knowledge gaps and formulate ideas for future research priorities in pulmonary vascular disease in line with National Heart, Lung, and Blood Institute Strategic Vision goals. The group identified opportunities to develop analytic approaches to multiomic datasets, to identify molecular pathways in pulmonary vascular disease pathobiology, and to link novel phenotypes to meaningful clinical outcomes. The committee suggested support for interdisciplinary research teams to develop and validate analytic methods, a national effort to coordinate biosamples and data, a consortium of preclinical investigators to expedite target evaluation and drug development, longitudinal assessment of molecular biomarkers in clinical trials, and a task force to develop a master clinical trials protocol for pulmonary vascular disease.