目的:前列腺癌是一种常见的疾病,主要的治疗方法之一是雄激素剥夺治疗,这是一种具有致残副作用的疗法。非药物干预(NPI)是有证据的,对人类健康的非侵入性干预措施。它们分为五类(物理,心理,营养,数字,元素)。NPI领域正在蓬勃发展,在这种情况下仍未得到充分利用。
方法:根据PRISMA指南(系统评价和Meta分析的首选报告项目)对随机对照试验进行系统评价。我们使用了“Medline”和“KalyaResearch”数据库。搜索和选择合格出版物后,我们纳入了37项随机对照试验.
结果:大多数文章涉及30项临床研究的物理NPI,3份出版物涉及营养NPI,2篇与心理NPI有关的文章和2篇与基本NPI有关的文章。未找到有关数字NPI的出版物。所有研究都旨在控制和改善治疗的副作用。没有基本的NPI显示出益处。只有一种心理NPI和一种营养NPI有效。五种类型的物理NPI方案已显示出功效。与身体能力有关的主要好处,身体成分,骨质疏松,生活质量,疲劳,降低心血管风险,最终焦虑和抑郁。
结论:非药物干预措施,尤其是身体上的,在管理和减少与雄激素剥夺治疗相关的副作用方面是有效的,应该在这种情况下提供给患者。
OBJECTIVE: Prostate cancer is a frequent disease and one of the main treatments used is androgen deprivation therapy, which is a therapy with disabling side effects. Non-pharmacological interventions (NPIs) are evidenced based, non-invasive interventions on human health. They are classified into five categories (physical, psychological, nutritional, digital, elemental). The NPIs sphere is booming and still remains underused in this context.
METHODS: A systematic
review concerning randomized controlled trials was executed according to the PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). We used the \"Medline\" and \"Kalya Research\" databases. After searching and selecting eligible publications, we included 37 randomized controlled trials.
RESULTS: The majority of articles concerned physical NPIs with 30 clinical studies, 3 publications dealt with nutritional NPIs, 2 with psychological NPIs and 2 articles concerned elemental NPIs. No publication about digital NPI was found. All of the studies aimed to manage and improve the side effects of treatment. No elemental NPI has demonstrated benefit. Only one psychological NPI and one nutritional NPI were effective. Five types of physical NPI protocols have shown efficacy. The main benefits related to physical abilities, body composition, osteoporosis, quality of life, fatigue, reduced cardiovascular risk and finally anxiety and depression.
CONCLUSIONS: Non-pharmacological interventions, especially physical ones, are effective in managing and reducing the side effects associated with androgen deprivation therapy and should be offered to patients in this context.