背景：川崎病（KD）的诊断主要基于临床发现并得到实验室检查的支持。完整的KD符合主要临床标准，而不完全KD包括主要标准较少、实验室或超声心动图检查结果一致的患者。这项研究比较了人口统计，临床,实验室,完整和不完整KD以及早期和晚期陈述者之间的超声心动图参数。此外，它描述了研究人群的冠状动脉表现。
方法：对2010年1月至2020年9月期间诊断为KD的所有患者进行回顾性分析。临床表现,实验室特点,超声心动图观察,并检查了随访数据。此外，患者被进一步分为早期患者(发热10天内出现)和晚期患者(疾病发作10天后出现).对人口统计进行了完整和不完整KD与早期和晚期演讲者之间的比较，临床,和超声心动图特征。
结果：共有76例患者确诊为KD。报告的中位年龄为28个月，5到144个月，中位时间是7天，范围为1到30天。中位随访期为6周,范围为1到192周。38例患者（50%）出现完全KD，和38（50％）有不完整的KD。皮肤表现，口腔粘膜改变，皮肤脱皮，结膜炎,完全KD患者的淋巴结肿大比不完全KD患者的淋巴结肿大。完全和不完全疾病在冠状动脉病变方面没有差异。在患者中，53（70％）在发烧后10天或更短的时间出现，和23（30％）出现在疾病发作的第10天之后。早期和晚期陈述者之间的比较显示，早期陈述者中的粘膜变化和淋巴结病表现明显更大，晚期陈述者中的冠状动脉病变明显更大。
结论：KD的临床特征应促使早期转诊进行评估，超声心动图,早期给予静脉注射免疫球蛋白以预防冠状动脉并发症。完整形式的川崎没有比不完整形式更频繁的冠状动脉病变。此外,晚期患者的冠状动脉异常风险可能比早期患者高.
BACKGROUND: The diagnosis of Kawasaki disease (KD) is based mainly on clinical findings and supported by laboratory tests. Complete KD fulfills the main clinical criteria, while incomplete KD includes patients with fewer main criteria and compatible laboratory or echocardiographic findings. The study compares the demographic, clinical, laboratory, and echocardiographic parameters between the complete and incomplete KD and early and late presenters. Moreover, it describes the coronary manifestations of the study population.
METHODS: A retrospective review of all patients admitted with a diagnosis of KD during the period from January 2010 to September 2020 was conducted. Clinical presentation, laboratory features, echocardiographic observations, and follow-up data were examined. Moreover, the patients were further classified as early presenters (presented within 10 days of fever onset) and late presenters (presented after 10 days of disease onset). A comparison between complete and incomplete KD and early and late presenters was performed for demographic, clinical, and echocardiographic features.
RESULTS: A total of 76 patients were admitted with a diagnosis of KD. The median age of presentation was 28 months, with a range of five to 144 months, and the median timing was seven days, with a range of one to 30 days. The median follow-up period was six weeks, with a range of one to 192 weeks. Complete KD was present in 38 patients (50%), and 38 (50%) had incomplete KD. Skin manifestations, oral mucosal changes, skin desquamation, conjunctivitis, and lymphadenopathy were present more in patients with complete KD than incomplete ones. Complete and incomplete diseases did not differ regarding coronary artery lesions. Of the patients, 53 (70%) presented 10 days or less after the onset of fever, and 23 (30%) presented after the 10th day of disease onset. Comparison between early and late presenters revealed significantly greater mucus membrane changes and lymphadenopathy manifestations among the early presenters and coronary artery lesions among the late presenters.
CONCLUSIONS: The clinical features of KD should prompt early referral for evaluation, echocardiography, and early administration of intravenous immunoglobulin to prevent coronary artery complications. The complete form of Kawasaki does not have more frequent coronary artery lesions than the incomplete form. Additionally, late presenters may be at increased risk for coronary artery abnormalities than early presenters.
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