■患有先天性免疫错误(IEI)的患者会反复感染,自身免疫,和恶性肿瘤。由于重复的医疗程序,需要持续的治疗和监测,以及不可预测的疾病进程,IEI患者容易出现精神健康障碍,包括焦虑。在这项研究中,我们旨在评估波兰成年IEI患者焦虑症状的患病率和水平,并探讨该组患者焦虑的决定因素.
■通过医院焦虑和抑郁量表(HADS)收集了105名波兰IEI患者的数据,简短的疾病感知问卷(B-IPQ),疾病认知问卷(ICQ),匹兹堡睡眠质量指数(PSQI)以及一份关于一般健康和人口统计数据的问卷。为了对数据进行统计分析,评估了定量数据的分布的正常性,并使用Cronbach的α系数研究了测试的内部一致性;此外,我们进行了相关性和组间差异的分析,和路径分析来探索因果关系。在p<0.050时考虑显著性。
■38例(36.2%)患者出现焦虑症状(HADS-A≥8);14例(13.3%)患者出现严重焦虑(评分≥11),24例(22.9%)有中度焦虑(8-10分)。睡眠质量差的患者,疼痛频率更高,年龄较小,没有固定收入的人比其他人有更高的焦虑分数。疾病的情绪和认知表征与焦虑水平呈正相关。强烈的焦虑与更消极的疾病感知有关,更高的无助感,较低的疾病接受度,和较低的感知利益。
■焦虑在IEI患者中很常见。然而,结果表明,它与更严重的IEI病程或几种合并症无关,然而,疼痛频率和睡眠质量差被认为是焦虑的重要临床因素.因为焦虑与负面的疾病感知有关,心理治疗可能适用于这组患者。
UNASSIGNED: Patients with inborn errors of immunity (IEI) experience recurrent infections, autoimmunity, and malignancies. Owing to repeated medical procedures, the need for constant treatment and surveillance, and the unpredictable course of the disease, patients with IEI are prone to develop mental health disorders, including anxiety. In this
study, we aimed to assess the prevalence and level of anxiety symptoms in adult Polish patients with IEI and explore the determinants of anxiety in this group of patients.
UNASSIGNED: Data from 105 Polish patients with IEI were collected via the hospital anxiety and depression scale (HADS), brief illness perception questionnaire (B-IPQ), illness cognition questionnaire (ICQ), Pittsburgh sleep quality index (PSQI), and a questionnaire on general health and demographic data. For statistical analyses of data, the normality of distribution of quantitative data was assessed, and internal consistency of tests was investigated using Cronbach\'s alpha coefficient; moreover, we performed the analysis of correlations and between-group differences, and path analysis to explore causal relationships. Significance was considered at p < 0.050.
UNASSIGNED: Thirty-eight (36.2%) patients had anxiety symptoms (HADS-A ≥ 8); 14 (13.3%) patients had severe anxiety (score ≥ 11), and 24 (22.9%) had moderate anxiety (score of 8-10). Patients with poor sleep quality, higher pain frequency, younger age, and no fixed income had higher anxiety scores than others. Emotional and cognitive representations of illness were positively correlated with anxiety levels. Intense anxiety was related to more negative illness perception, higher helplessness, lower illness acceptance, and lower perceived benefits.
UNASSIGNED: Anxiety is common in patients with IEI. However, results indicate that it is not related to a more severe course of IEI or several comorbidities, whereas, pain frequency and poor sleep quality were identified to be important clinical factors for anxiety. Because anxiety was related to negative illness perception, psychological therapy may apply to this group of patients.