■Oligodontia是一种罕见的遗传病,其特征是超过六个先天性牙齿缺失,作为孤立的非综合征或与其他遗传综合征有关。WNT10A变体对牙齿发育的影响随着c.321C>A变体的存在和缺失牙齿的数量而增加。
■一名21岁的非综合征少牙症男子在15岁时被诊断为牙齿错位,言语问题,没有24颗恒牙.开始了专家之间的跨学科合作,以实现全面治疗。DNA分析证实该患者是已知致病性WNT10A变异体c321C>A和WNT10A变异体c.113G>T的携带者,其临床意义未知。
■牙科植入物是一种常见的治疗方法;然而,青少年非综合征型少突症患者的骨发育挑战需要仔细规划,以确保植入成功.许多WNT变异体在牙齿发育中起着至关重要的作用,并直接参与非综合征性少牙。尤其是WNT10变体c.321C>A.
■全牙弓植入物支持的整体式氧化锆螺钉保留的固定假体对于患有非综合征性寡牙症的年轻人来说是一种可行的治疗选择。需要进一步的研究来阐明WNT10A变体c321C>A和c.113G>T对非综合征性寡交的致病表型的可能放大作用。
UNASSIGNED: Oligodontia is a rare genetic condition characterized by more than six congenitally missing teeth, either as an isolated non-syndromic condition or in association with other genetic syndromes. The impact of WNT10A variants on dental development increases with the presence of the c.321C>A variant and the number of missing teeth.
UNASSIGNED: A 21-year-old man with non-syndromic oligodontia was diagnosed at 15 years of age with misaligned teeth, speech problems, and the absence of 24 permanent teeth. Interdisciplinary collaboration between specialists was initiated to enable comprehensive treatment. DNA analysis confirmed that the patient was a carrier of the known pathogenic WNT10A variant c321C>A and WNT10A variant c.113G>T of unknown clinical significance.
UNASSIGNED: Dental implants are a common treatment; however, bone development challenges in adolescent patients with non-syndromic oligodontia necessitate careful planning to ensure implant success. Many WNT variants play crucial roles in tooth development and are directly involved in non-syndromic oligodontia, especially the WNT10 variant c.321C>A.
UNASSIGNED: A full-arch implant-supported monolithic zirconia screw-retained fixed prosthesis is a viable treatment option for young adults with non-syndromic oligodontia. Further studies are needed to clarify the possible amplifying effect of the WNT10A variants c321C>A and c.113G>T on the pathogenic phenotype of non-syndromic oligodontia.