本文旨在回顾目前已知的动物和人类冠状病毒及其细胞受体之间的相互作用。在过去的20年里,已经出现了三种新的冠状病毒，它们在人类中引起了严重的疾病，包括SARS-CoV-2（严重急性呼吸道综合症病毒2）；因此，更深入地了解冠状病毒宿主与细胞的相互作用至关重要.受体结合是冠状病毒在复制之前进入的第一阶段，并且可以通过刺突蛋白（负责识别细胞表面受体的冠状病毒表面糖蛋白）内的微小变化来改变。冠状病毒对受体的识别也是感染的主要决定因素，向性,和发病机制，并作为宿主免疫监视和其他潜在干预策略的关键靶标。我们的目标是强调在SARS-CoV-2大流行之后，需要继续深入了解这一主题领域，有可能发生更多的人畜共患传播事件。我们也承认需要对聚糖-冠状病毒相互作用进行更有针对性的研究，因为这是动物到人类的人畜共患溢出事件，随着聚糖结合能力的改变，对于其他病毒，如流感A。
This article aims to
review all currently known interactions between animal and human coronaviruses and their cellular receptors. Over the past 20 years, three novel coronaviruses have emerged that have caused severe disease in humans, including SARS-CoV-2 (severe acute respiratory syndrome virus 2); therefore, a deeper understanding of coronavirus host-cell interactions is essential. Receptor-binding is the first stage in coronavirus entry prior to replication and can be altered by minor changes within the spike protein-the coronavirus surface glycoprotein responsible for the recognition of cell-surface receptors. The recognition of receptors by coronaviruses is also a major determinant in infection, tropism, and pathogenesis and acts as a key target for host-immune surveillance and other potential intervention strategies. We aim to highlight the need for a continued in-depth understanding of this subject area following on from the SARS-CoV-2 pandemic, with the possibility for more zoonotic transmission events. We also acknowledge the need for more targeted research towards glycan-coronavirus interactions as zoonotic spillover events from animals to humans, following an alteration in glycan-binding capability, have been well-documented for other viruses such as Influenza A.
