■文献表明，压力可能在急性中心性浆液性脉络膜视网膜病变（CSC）的沉淀中起关键作用，因为脉络膜视网膜的完整性会受到患者社会心理状态的影响，表明需要生物标志物。不仅身体压力，而且心理压力会导致许多类型的身体障碍。然而,对应激引起的疾病的病理生理学知之甚少。这项研究的目的是研究血清因子是否可能参与应激诱发的眼部疾病的发展。
■该观察性病例系列包括33例接受初治急性CSC治疗的连续患者的33只眼。50名年龄匹配的健康志愿者的50只眼作为非CSC对照被包括在该研究中。收集所有参与者的血清样本，通过定量实时（RT）-PCR测量线粒体DNA（mtDNA）的水平。高迁移率族蛋白（HMGB）1和8-羟基-2'-脱氧鸟苷（8-OHdG）的血清水平，急性/慢性炎症和氧化应激的生物标志物，也被测量了。血清mtDNA，8-OHdG,和HMGB1浓度通过多元回归分析进行调查，以及对临床数据的评估。
■在未治疗急性CSC组中，血清mtDNA水平（36.5±32.4ng/mL）明显高于对照组（7.4±5.9ng/mL；p<0.001）。初治急性CSC患者血清8-OHdG和HMGB1水平测量为0.12±0.08ng/mL和18.1±35.0ng/mL，分别,表明与对照组相比，CSC中HMGB1水平升高。多因素回归分析显示血清mtDNA水平升高与浆液性视网膜脱离高度显著相关。
■我们显示血清mtDNA和HMGB1水平升高及其与CSC临床活动的关系，表明血清mtDNA和HMGB1可以作为疾病急性期的生物标志物。这些生物标志物的使用使得预测疾病发作和确定疾病严重程度成为可能。
UNASSIGNED: The literature suggests that stress may play a pivotal role in the precipitation of acute central serous chorioretinopathy (CSC) because chorioretinal integrity can be affected by the psychosocial state of the patient, indicating the need for a biomarker. Not only physical stress but also psychological stress causes many types of physical disorders. However, little is known about the pathophysiology of stress-induced disease. The objective of this
study was to investigate whether serum factors might be involved in the development of stress-induced ocular diseases.
UNASSIGNED: This observational case series included 33 eyes of 33 consecutive patients with treatment-naïve acute CSC. Fifty eyes of 50 age-matched healthy volunteers were included in this
study as non-CSC controls. Serum samples were collected from all participants, and the levels of mitochondrial DNA (mtDNA) were measured by quantitative real-time (RT)-PCR. Serum levels of high-mobility group box (HMGB) 1 and 8-hydroxy-2\'-deoxyguanosine (8-OHdG), biological markers of acute/chronic inflammation and oxidative stress, were also measured. The relationships between serum mtDNA, 8-OHdG, and HMGB1 concentrations were investigated by multivariate regression analysis, alongside an assessment of clinical data.
UNASSIGNED: In the treatment-naïve acute CSC group, the serum mtDNA levels (36.5 ± 32.4 ng/mL) were significantly higher than the levels in the control group (7.4 ± 5.9 ng/mL; p < 0.001). Serum levels of 8-OHdG and HMGB1 in treatment-naïve acute CSC patients measured 0.12 ± 0.08 ng/mL and 18.1 ± 35.0 ng/mL, respectively, indicating that HMGB1 levels were elevated in CSC compared with the control group. Multivariable regression analysis demonstrated that increased serum mtDNA levels were significantly associated with the height of serous retinal detachment.
UNASSIGNED: We showed serum mtDNA and HMGB1 level elevation and its relation to the clinical activities of CSC, indicating that serum mtDNA and HMGB1 could serve as biomarkers for the acute phase of the disease. The use of these biomarkers makes it possible to predict disease onset and determine disease severity.
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