■先兆子痫对女性构成更高的风险,特别是在溶血的发展中,肝酶升高,和低血小板(HELLP)综合征,导致母亲和新生儿的不良后果。与血压正常的孕妇相比,先兆子痫妇女的HELLP综合征的发生率往往更高。然而,在先兆子痫的背景下,缺乏HELLP综合征发生频率的研究,特别是在加纳。此外,血清红细胞腺苷酸激酶(EAK)的潜在预测价值,溶血的标志,预期先兆子痫的发作仍未被探索。
■在2020年5月至2022年4月之间进行,这项研究在战争纪念馆和上东区医院采用了病例对照方法。共有291名孕妇参加,包括111名诊断为先兆子痫和180名对照受试者,年龄在18至43岁之间。收集静脉血样并进行血小板计数分析,天冬氨酸转氨酶(AST),丙氨酸氨基转移酶(ALT),乳酸脱氢酶(LDH),和EAK,利用自动分析仪,除了ELISA技术。HELLP综合征的诊断是使用密西西比州三重定义建立的。
■与对照组相比,先兆子痫组的中位血清ALT水平(四分位数范围)显着升高[20.0(13.7-27.0)与13.0(9.4-18.6);p<0.001]。此外,与对照组(1/180;0.6%)相比,在先兆子痫病例中,密西西比州3级HELLP综合征的发生率明显较高(2/111;1.8%).血清ALT作为先兆子痫的优越预测因子,表现优于LDH(与0.58相比,曲线下面积为0.73)。ALT的敏感性和特异性分别为47.8%和87.2%,分别。
■尽管子痫前期病例中HELLP综合征的发生率相对较低,由于预计在中低收入国家先兆子痫的患病率将上升,这种情况可能会升级。
UNASSIGNED: Preeclampsia poses a heightened risk for women, particularly in the development of
hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome, leading to adverse outcomes for both mothers and newborns. The incidence of HELLP syndrome tends to be notably higher among women with preeclampsia compared with those with normotensive pregnancies. However, there is a dearth of research on the frequency of HELLP syndrome within the context of preeclampsia specifically in Ghana. Furthermore, the potential predictive value of serum erythrocyte adenylate kinase (EAK), a marker of
hemolysis, in anticipating the onset of preeclampsia remains largely unexplored.
UNASSIGNED: Conducted between May 2020 and April 2022, this research employed a
case-control methodology at the War Memorial and Upper East Regional Hospitals. A total of 291 pregnant women participated, comprising 111 diagnosed with preeclampsia and 180 control subjects, aged between 18 and 43 years. Venous blood samples were collected and subjected to analysis for platelet count, aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), and EAK, utilizing automated analyzers, alongside the ELISA technique. Diagnosis of HELLP syndrome was established using the Mississippi triple-class definition.
UNASSIGNED: The median serum ALT level (with interquartile range) was significantly elevated in the preeclampsia group compared with controls [20.0 (13.7-27.0) vs. 13.0 (9.4-18.6); p < 0.001]. Moreover, the frequency of Mississippi class 3 HELLP syndrome was notably higher among preeclampsia cases (2/111; 1.8%) compared with controls (1/180; 0.6%). Serum ALT emerged as the superior predictor of preeclampsia, outperforming LDH (with an area under the curve of 0.73 compared with 0.58). The sensitivity and specificity of ALT were measured at 47.8% and 87.2%, respectively.
UNASSIGNED: Although the occurrence of HELLP syndrome in preeclampsia cases appears relatively low, it may escalate as the prevalence of preeclampsia is anticipated to rise in low and middle-income nations.