背景:精确和正确的先天性异常分类在流行病学研究中很重要,不仅要根据病因进行分类,而且要将相似的先天性异常分组在一起,创建同质亚组进行监测和研究。本文介绍了先天性异常的更新的EUROCAT(欧洲先天性异常监测)亚组和更新的多重先天性异常(MCA)算法,并提供了修订的基本论点。
方法:描述了EUROCAT方法。此外,我们展示了我们如何验证修订的EUROCAT子组和MCA算法,两者都基于国际疾病分类(ICD10/ICD9)代码。
结果:详细描述了更新的EUROCAT子组和更新的MCA算法,并将更新的版本与以前的版本进行了比较。
结论:EUROCAT亚组和MCA算法为先天性异常研究和先天性异常的流行病学监测提供了标准化和明确的方法,以促进识别致畸暴露并评估一级预防和产前筛查政策的影响。EUROCAT子组和MCA算法可通过EUROCAT数据库管理软件免费提供给其他研究人员。
BACKGROUND: Precise and correct classification of congenital anomalies is important in epidemiological studies, not only to classify according to etiology but also to group similar congenital anomalies together, to create homogeneous subgroups for surveillance and research. This paper presents the updated EUROCAT (European surveillance of congenital anomalies) subgroups of congenital anomalies and the updated multiple congenital anomaly (MCA) algorithm and provides the underlying arguments for the revisions.
METHODS: The EUROCAT methodology is described. In addition, we show how we validated the revised EUROCAT subgroups and MCA algorithm, which are both based on the International Classification of Diseases (ICD10/ICD9) codes.
RESULTS: The updated EUROCAT subgroups and the updated MCA algorithm are described in detail and the updated version is compared to the previous versions.
CONCLUSIONS: The EUROCAT subgroups and MCA algorithm provide a standardized and clear methodology for congenital anomaly research and epidemiological surveillance of congenital anomalies in order to facilitate the identification of teratogenic exposures and to assess the impact of primary prevention and prenatal screening policies. The EUROCAT subgroups and MCA algorithm are made freely available for other researchers via the EUROCAT Database Management Software.