褪黑素是一种多功能的激素调节剂,通过昼夜节律维持体内平衡,这些节律的不同步会导致胃肠道疾病并增加患癌症的风险。初步临床研究表明,外源性褪黑素能减轻抗癌治疗的有害作用,提高生活质量,但由于研究的异质性,结果仍然没有定论。在以患者为中心的N-of-1研究中,一种个性化的方法来测试临床参数和对无毒且生物可利用的褪黑激素综合治疗的反应,值得更多关注。本文对结肠癌的临床病例进行分析和讨论,化疗的副作用,和炎症标志物的动力学(NLR,LMR,和PLR比率),肿瘤(CEA,CA19-9和PSA),和止血(D-二聚体和活化部分凝血活酶时间)。患者在化疗期间和之后服用褪黑素,营养素(锌,硒,维生素D,绿茶,和taxifolin),化疗后还有阿司匹林.患者的PSA水平在CT联合褪黑素(19毫克/天)期间下降,褪黑素使炎症标志物正常化,多发性神经病的症状减轻,但对血小板减少症没有帮助.结果在关于肿瘤缓解和全身效应的文献中进行分析和讨论,缓解治疗介导的不良反应,与生存联系,和N-of-1研究。
Melatonin is a multifunctional hormone regulator that maintains homeostasis through circadian rhythms, and desynchronization of these rhythms can lead to gastrointestinal disorders and increase the risk of cancer. Preliminary clinical studies have shown that exogenous melatonin alleviates the harmful effects of anticancer therapy and improves quality of life, but the results are still inconclusive due to the heterogeneity of the studies. A personalized approach to testing clinical parameters and response to integrative treatment with nontoxic and bioavailable melatonin in patient-centered N-of-1 studies deserves greater attention. This clinical
case of colon cancer analyzes and discusses the tumor pathology, the adverse effects of chemotherapy, and the dynamics of markers of inflammation (NLR, LMR, and PLR ratios), tumors (CEA, CA 19-9, and PSA), and hemostasis (D-dimer and activated partial thromboplastin time). The patient took melatonin during and after chemotherapy, nutrients (zinc, selenium, vitamin D, green tea, and taxifolin), and aspirin after chemotherapy. The patient\'s PSA levels decreased during CT combined with melatonin (19 mg/day), and melatonin normalized inflammatory markers and alleviated symptoms of polyneuropathy but did not help with thrombocytopenia. The results are analyzed and discussed in the context of the literature on oncostatic and systemic effects, alleviating therapy-mediated adverse effects, association with survival, and N-of-1 studies.