背景:SenecavirusA(SVA),Picornaviridae家族的一员,是新发现的,导致水疱性病变,猪的跛行,甚至新生仔猪死亡。SVA近年来在全球范围内迅速传播,尤其是在亚洲。
目的:我们进行了一项全球荟萃分析和系统评价,以确定猪SVA感染的状况。
方法:通过PubMed,VIP中文期刊数据库,中国国家知识基础设施,和万方数据搜索2014年至2020年7月26日的数据,根据我们的纳入标准,共有34篇文章被纳入本分析。我们通过随机效应模型估计了猪中SVA的合并患病率。进行了研究的偏倚风险评估和亚组分析以解释异质性。
结果:我们估计SVA患病率为15.90%(1,564/9,839;95%置信区间[CI],44.75-65.89)全球。2016年后患病率降至11.06%(945/8,542;95%CI,28.25-50.64)。基于VP1的RT-PCR和免疫组织化学检测的最高SVA患病率为58.52%(594/1,015;95%CI,59.90-83.96)和85.54%(71/83;95%CI,76.68-0.00),分别。此外,仔猪群中SVA的患病率最高,为71.69%(119/166;95%CI,68.61-98.43)(p<0.05)。此外,我们的分析证实了亚组,包括国家,采样年,采样位置,检测到的基因,检测方法,季节,年龄,和气候,可能是与SVA患病率相关的异质性因素。
结论:结果表明,SVA目前在各个国家广泛存在。因此,应提出更多的预防和控制政策,以加强对猪场的管理,改善饲养条件和环境,以减少SVA的传播。
BACKGROUND: Senecavirus A (SVA), a member of the family Picornaviridae, is newly discovered, which causes vesicular lesions, lameness in swine, and even death in neonatal piglets. SVA has rapidly spread worldwide in recent years, especially in Asia.
OBJECTIVE: We conducted a global meta-analysis and systematic
review to determine the status of SVA infection in pigs.
METHODS: Through PubMed, VIP Chinese Journals Database, China National Knowledge Infrastructure, and Wanfang Data search data from 2014 to July 26, 2020, a total of 34 articles were included in this analysis based on our inclusion criteria. We estimated the pooled prevalence of SVA in pigs by the random effects model. A risk of bias assessment of the studies and subgroup analysis to explain heterogeneity was undertaken.
RESULTS: We estimated the SVA prevalence to be 15.90% (1,564/9,839; 95% confidence interval [CI], 44.75-65.89) globally. The prevalence decreased to 11.06% (945/8,542; 95% CI, 28.25-50.64) after 2016. The highest SVA prevalence with the VP1-based RT-PCR and immunohistochemistry assay was 58.52% (594/1,015; 95% CI, 59.90-83.96) and 85.54% (71/83; 95% CI, 76.68-100.00), respectively. Besides, the SVA prevalence in piglet herds was the highest at 71.69% (119/166; 95% CI, 68.61-98.43) (p < 0.05). Moreover, our analysis confirmed that the subgroups, including country, sampling year, sampling position, detected gene, detection method, season, age, and climate, could be the heterogeneous factors associated with SVA prevalence.
CONCLUSIONS: The results indicated that SVA widely exists in various countries currently. Therefore, more prevention and control policies should be proposed to enhance the management of pig farms and improve breeding conditions and the environment to reduce the spread of SVA.