■氙气在动物模型中对各种神经系统损伤表现出显著的神经保护作用。然而,在人类神经损伤研究中,氙气改善结局的临床证据仍然难以捉摸.以前对氙气作用方法的审查尚未以系统的方式进行。这篇综述的目的是全面总结与氙气给药有关的两种现象的细胞相互作用的证据:麻醉和神经保护。
■根据PRISMA指南对临床前文献进行了系统评价,并在PROSPERO注册了评价方案。该综述包括中枢神经系统的体外模型和哺乳动物体内研究。搜索于2022年5月27日在以下数据库中进行:OvidMedline,OvidEmbase,OvidEmcare,APAPsycInfo,和WebofScience。使用健康评估和翻译工具办公室进行偏见风险评估。鉴于结果数据的异质性,进行了叙事合成。
■该评论确定了69篇文章,描述了638个单独的实验,其中测试了有关氙气与细胞靶标相互作用的假设,包括:膜结合蛋白,细胞内信号级联和转录因子。氙与离子型谷氨酸受体具有共同的和亚型特异性的相互作用。氙还影响抑制性神经递质的释放,并影响多种其他配体门控和非配体门控膜结合蛋白。该综述确定了受氙气给药影响的几种细胞内信号通路和基因转录因子,并可能有助于麻醉和神经保护。
■氙NMDA受体拮抗作用的性质,以及它的额外细胞靶标的范围,区别于其他NMDA拮抗剂如氯胺酮和一氧化二氮。这反映在氙气的独特行为和电生理特征中。氙气影响多个重叠的细胞过程,在细胞膜和细胞内,促进细胞存活。希望识别氙气的潜在细胞靶标可能有助于开发用于神经损伤的潜在疗法并提高氙气的临床利用率。
■https://www.crd.约克。AC.英国/普华永道/,标识符:336871。
UNASSIGNED: Xenon exhibits significant neuroprotection against a wide range of neurological insults in animal models. However, clinical evidence that xenon improves outcomes in human studies of neurological injury remains elusive. Previous reviews of xenon\'s method of action have not been performed in a systematic manner. The aim of this
review is to provide a comprehensive summary of the evidence underlying the cellular interactions responsible for two phenomena associated with xenon administration: anesthesia and neuroprotection.
UNASSIGNED: A systematic
review of the preclinical literature was carried out according to the PRISMA guidelines and a
review protocol was registered with PROSPERO. The
review included both in vitro models of the central nervous system and mammalian in vivo studies. The search was performed on 27th May 2022 in the following databases: Ovid Medline, Ovid Embase, Ovid Emcare, APA PsycInfo, and Web of Science. A risk of bias assessment was performed utilizing the Office of Health Assessment and Translation tool. Given the heterogeneity of the outcome data, a narrative synthesis was performed.
UNASSIGNED: The
review identified 69 articles describing 638 individual experiments in which a hypothesis was tested regarding the interaction of xenon with cellular targets including: membrane bound proteins, intracellular signaling cascades and transcription factors. Xenon has both common and subtype specific interactions with ionotropic glutamate receptors. Xenon also influences the release of inhibitory neurotransmitters and influences multiple other ligand gated and non-ligand gated membrane bound proteins. The review identified several intracellular signaling pathways and gene transcription factors that are influenced by xenon administration and might contribute to anesthesia and neuroprotection.
UNASSIGNED: The nature of xenon NMDA receptor antagonism, and its range of additional cellular targets, distinguishes it from other NMDA antagonists such as ketamine and nitrous oxide. This is reflected in the distinct behavioral and electrophysiological characteristics of xenon. Xenon influences multiple overlapping cellular processes, both at the cell membrane and within the cell, that promote cell survival. It is hoped that identification of the underlying cellular targets of xenon might aid the development of potential therapeutics for neurological injury and improve the clinical utilization of xenon.
UNASSIGNED: https://www.crd.york.ac.uk/prospero/, identifier: 336871.