■FV,MTHFR,II,PAI-I是最常见的与血栓性遗传变异相关的基因,在不同的人口和种族之间有所不同。关于这些变体在约旦的流行和多重性知之甚少。这项研究的目的是估计FVG1691A的患病率和多重性,FVH1299R,MTHFR1298A>C,MTHFR677C>T,二20210G>A,健康约旦人的PAI-I6754G/5G变体。
■这项横断面研究是对随机选择的健康约旦参与者进行的。非约旦人和有动脉/静脉血栓形成病史的人,动脉粥样硬化,或复发性流产史被排除在研究之外.PCR用于检测从参与者血液样本中提取的DNA变异。
■总共筛选了300名受试者:170名(56.7%)女性,平均年龄为27.78±9.32岁,130名(43.3%)男性,平均年龄为29.88±8.55岁。在75%的受试者中发现了遗传变异(至少一种)(女性为81.2%,男性为66.9%),而64.7%,52%,12%的人被发现至少有两个,三,和四个变体,分别。总的来说,21%,29%,54.3%,27.3%,7.7%,66%的参与者被发现患有FVG1691A,FVH1299R,MTHFR1298A>C,MTHFR677C>T,二20210G>A,和PAI-I6754G/5G基因变异,分别。
■我们四分之三的人口至少有一种血栓性遗传变异,大多数都有不止一个变种。检测到的最常见变异与MTHFR相关,其次是PAI-I,FV,然后是II。我们观察到女性的患病率估计高于男性。然而,男性的多重性明显高于女性。我们的发现表明,与其他人群相比,患病率估计值存在明显差异。
UNASSIGNED: FV, MTHFR, II, and PAI-I are the most common genes associated with thrombophilia genetic variants, which vary among different populations and ethnic groups. Little is known about the prevalence and multiplicity of these variants in Jordan. The aim of this
study was to estimate the prevalence and multiplicity of the FV G1691A, FV H1299R, MTHFR 1298A>C, MTHFR 677C>T, II 20210G>A, and PAI-I 675 4G/5G variants among healthy Jordanians.
UNASSIGNED: This cross-sectional
study was conducted on randomly selected healthy Jordanian participants. Non-Jordanians and those with a history of arterial/venous thrombosis, atherosclerosis, or a history of recurrent abortions were excluded from the
study. PCR was used to detect variants in DNA extracted from participants\' blood samples.
UNASSIGNED: A total of 300 subjects were screened: 170 (56.7%) females with an average age of 27.78±9.32 years and 130 (43.3%) males with an average age of 29.88±8.55 years. Genetic variants (at least one) were found in 75% of the subjects (81.2% among females and 66.9% among men), while 64.7%, 52%, and 12% were found to have at least two, three, and four variants, respectively. Overall, 21%, 29%, 54.3%, 27.3%, 7.7%, and 66% of participants were found to have FV G1691A, FV H1299R, MTHFR 1298A>C, MTHFR 677C>T, II 20210G>A, and PAI-I 675 4G/5G gene variants, respectively.
UNASSIGNED: Three-quarters of our population had at least one of the thrombophilia genetic variants, and most had more than one variant. The most common variants detected were associated with MTHFR, followed by PAI-I, FV, and then II. We observed that females had higher prevalence estimates than males. However, multiplicity among males was significantly higher than females. Our findings indicated noticeable differences in prevalence estimates compared with other populations.