木糖醇,作为一种替代低热量甜味剂在各种糖果和保健产品的配方中被广泛接受。在世界范围内,它是通过在高温和高压下对纯d-木糖溶液进行催化氢化而在工业上生产的。生物技术木糖醇生产是化学过程的潜在有吸引力的替代品,因为它发生在更温和的工艺条件下,并且可以基于来自低成本工业和农业废物的糖混合物。然而,到目前为止,木糖醇生产的微生物发酵途径尚未在工业上实践。这篇综述强调了生物技术木糖醇生产的挑战和前景,考虑到发酵微生物的可能遗传修饰以及工业生物加工和产品下游的各个方面。
Xylitol, as an alternative low calorie sweetener is well accepted in formulations of various confectioneries and healthcare products. Worldwide it is industrially produced by catalytic hydrogenation of pure d-xylose solution under high temperature and pressure. Biotechnological xylitol production is a potentially attractive replacement for chemical process, as it occurs under much milder process conditions and can be based on sugar mixtures derived from low-cost industrial and agri-waste. However, microbial fermentation route of xylitol production is not so far practiced industrially. This
review highlights the challenges and prospects of biotechnological xylitol production considering possible genetic modifications of fermenting microorganisms and various aspects of industrial bioprocessing and product downstreaming.