精神分裂症是一种导致社会和职业功能障碍的严重慢性精神疾病。我们在这篇综述文章中的主要重点是进一步分析精神分裂症患者颞叶的结构和功能改变,这可能会导致我们在这种疾病中经常看到的相关表现。我们的目标是看看颞叶异常之间是否有任何相关性,更具体地说,大脑体积和特定症状如听觉和语言处理的改变,等。在大多数研究中,颞叶的体积改变与思维障碍之间存在正相关。然而,在一些研究中,颞上回体积也与幻觉和思维障碍的严重程度呈负相关。我们在文章搜索中通过PubMed数据库使用了医学主题标题(MeSH)搜索策略,产生了241篇论文。在应用特定的纳入和排除标准后,审查了最后30个。从我们的研究来看,精神分裂症中颞叶及其灰质和白质体积改变的参与是非常明显的;然而,潜在生物过程的确切机制尚未得到彻底研究。因此,对结合不同成像模式的更大队列的进一步研究,包括容量,扩散张量,和功能成像需要解释进行性大脑变化如何影响各种结构,功能,和精神分裂症颞叶的代谢活动。
Schizophrenia is a severe chronic mental illness leading to social and occupational dysfunction. Our primary focus in this
review article was to analyze further the structural and functional alterations of the temporal lobe in patients with schizophrenia, which might contribute to the associated manifestations we often see in this illness. Our goal was to see if there was any correlation between temporal lobe abnormalities, more specifically, alterations in brain volume and specific symptoms such as auditory and language processing, etc. There is a positive correlation between volume alterations and thoughts disorders in the temporal lobe in the majority of studies. However, superior temporal gyrus volume has also been correlated negatively with the severity of hallucinations and thought disorders in some studies. We utilized Medical Subject Heading (MeSH) search strategy via PubMed database in our articles search yielding 241 papers. After the application of specific inclusion and exclusion criteria, a final number of 30 was reviewed. The involvement of the temporal lobe and its gray and white matter volume alterations in schizophrenia is quite apparent from our research; however, the exact mechanism of the underlying biological process is not thoroughly studied yet. Therefore, further research on larger cohorts combining different imaging modalities including volumetry, diffusion tensor, and functional imaging is required to explain how the progressive brain changes affect the various structural, functional, and metabolic activities of the temporal lobe in schizophrenia.