背景:涉及语言的大脑网络,在词汇决策(LD)过程中,功能磁共振成像可以检测到注意力和反应过程。这里,我们调查了双相情感障碍(BD)患者LD相关功能网络的可能异常.
方法:比较BD(n=25)和对照组(n=21)的功能磁共振成像和行为数据,年龄和性别相匹配的群体。通过操纵LD刺激的“单词相似度”并使用多维分析方法来提取LD中涉及的功能性大脑网络。
结果:注意,反应和语言过程被捕获在单独的功能特定的大脑网络(默认模式网络,响应网络,语言处理网络,分别)在BD组和对照组中,在一个独立的健康成年人组中复制我们先前的研究结果。行为上,BD组在LD任务中的表现高于对照组。默认模式网络(DMN)和语言处理网络(LPN)中的活动在组之间没有差异,但是BD组在反应网络(RESP)中的激活高于对照组。
结论:由于样本少,这项研究动力不足,只能检测到大的影响。
结论:结果表明,BD可能与RESP网络中的持续活动有关,这可能导致BD的精神运动功能障碍。未来的研究应该调查BD中RESP激活改变和精神运动障碍之间的可能联系。以及BD中RESP活性改变的基础。
BACKGROUND: Brain networks involved in language, attentional and response processes are detectable by fMRI during lexical decision (LD). Here, we investigated possible abnormalities in the functional networks involved in LD in patients with bipolar disorder (BD).
METHODS: fMRI and behavioural data were compared between BD (n = 25) and control (n = 21), with groups matched for age and sex. The functional brain networks involved in LD were extracted by manipulating the \"word-likeness\" of LD stimuli and using a multidimensional analysis method.
RESULTS: Attentional, response and language processes were captured in separate function-specific brain networks (default mode network, response network, linguistic processing network, respectively) in the BD and control groups, replicating the results of our previous study in an independent group of healthy adults. Behaviourally, the BD group showed higher performance than the control group in the LD task. Activity in the default mode network (DMN) and the linguistic processing network (LPN) did not differ between the groups, but the BD group had higher activation than the control group in the response network (RESP).
CONCLUSIONS: Due to the small sample, the study is underpowered, capable of only detecting large effects.
CONCLUSIONS: The results suggest that BD may be associated with sustained activity in the RESP network, which might contribute to psychomotor dysfunction in BD. Future studies should investigate the possible link between altered RESP activation and psychomotor disturbances in BD, as well as the basis for altered RESP activity in BD.