背景:扁平苔藓(LPP)的特征是慢性瘢痕性脱发,这是进行性的,通常是治疗难治性的。目前的药物治疗是次优的,不适用于长期使用,因为副作用的可能性很高,保证更安全、更有效的治疗替代方案。
方法:基于我们先前使用局部植物制剂(Gashee)治疗中心性离心瘢痕性脱发患者的成功,我们回顾了4例经活检证实的LPP患者的记录,这些患者单独使用外用制剂或与口服制剂联合使用.三名患者先前通过病灶内注射类固醇治疗失败,局部米诺地尔,他克莫司,还有氯倍他索.体格检查和摄影文件也被用作结果指标。植物制剂的治疗持续时间为6周至9.5个月。
结果:所有患者的LPP活性替代指标总体改善,症状消失(瘙痒,压痛,头皮刺激,和头发脱落),头发生长的改善,减少发红。所有报告的满意度都很高,没有不良反应。
结论:治疗难治性LPP患者对一种新的植物学治疗有反应。据我们所知,这是LPP响应基于植物的自然处理的第一份发表的报告。有必要在更多患者的对照试验中对这种治疗进行进一步评估。
扁平苔藓是一种慢性进行性疾病,最常影响中年妇女。会导致头皮发炎,疤痕,最终永久性脱发。治疗通常是长期无效的,并且伴随着限制其使用的副作用。我们报告说,使用一种名为UGroGashee博士的新植物制剂作为唯一的治疗方法成功治疗了四名患者,持续时间为6周至9.5个月。局部施用或与其口服制剂组合施用治疗。所有患者均显示疾病进展停止,头发明显再生。他们还报告了头皮瘙痒的完全消退,压痛,和刺激,没有不良影响。我们的报告是首次发表的对基于植物的自然处理的扁平苔藓响应的研究,值得在更大的对照试验中进一步评估。
BACKGROUND: Lichen planopilaris (LPP) is characterized by chronic scarring alopecia that is progressive and typically refractory to therapy. Current drug treatments are suboptimal and not applicable for long-term use because of the high potential for adverse effects, warranting safer and more effective treatment alternatives.
METHODS: Based on our previous success in treating a patient with central centrifugal cicatricial alopecia using a topical botanical formulation (Gashee), we reviewed records of four patients with biopsy-proven LPP treated with the topical formulation alone or in combination with its oral preparation. Three patients had failed previous treatment with intralesional steroid injections, topical minoxidil, tacrolimus, and clobetasol. Physical examination and photographic documentation were also used as outcome measures. Treatment duration with the botanical formulations ranged from 6 weeks to 9.5 months.
RESULTS: All patients showed overall improvement in surrogate indicators of LPP activity as evidenced by the disappearance of symptoms (pruritus, tenderness, scalp irritation, and hair shedding), improvement in hair growth, and reduction in redness. All reported a high satisfaction level and no adverse effects.
CONCLUSIONS: Patients with treatment-refractory LPP responded to a novel botanical treatment. To the best of our knowledge, this is the first published report of LPP responding to a plant-based natural treatment. Further evaluation of this treatment in a controlled trial with a larger number of patients is warranted.
Lichen planopilaris is a chronic and progressive condition, most commonly affecting middle-aged women. It results in scalp inflammation, scarring, and ultimately permanent hair loss. Treatments are typically ineffective in the long term and are associated with side effects that limit their use. We report success in treating four patients using a new botanical formulation called Dr. UGro Gashee as the sole therapy for a duration ranging from 6 weeks to 9.5 months. The treatment was administered topically or in combination with its oral formulation. All the patients showed cessation of disease progression with significant hair regrowth. They also reported complete resolution of scalp itch, tenderness, and irritation, with no adverse effects. Our report is the first published study of lichen planopilaris responding to a plant-based natural treatment and warrants further evaluation in larger controlled trials.