肉毒杆菌中毒是由肉毒梭菌产生的神经毒素引起的一种罕见的神经肌肉疾病。婴儿肉毒中毒的诊断可能模糊或延迟,因为它的表现类似于婴儿神经肌肉疾病。我们报告了韩国首例婴儿肉毒中毒的急性进行性松软婴儿,其吸吮不良,哭声微弱。所有血液均未发现异常,脑脊液,基因测试,神经传导研究,和成像研究。最终在怀疑婴儿肉毒杆菌中毒的情况下进行了粪便毒素测试,结果是积极的。患者立即接受七价肉毒杆菌中毒抗毒素治疗。3个月后随访显示发育正常,所有症状完全缓解。因此,临床怀疑婴儿肉毒中毒,这是一种可治疗的婴儿神经肌肉疾病,对于软盘婴儿的早期诊断和及时治疗至关重要。
Botulism is a rare neuromuscular disorder caused by neurotoxins produced by Clostridium botulinum. The diagnosis of infant botulism may be obscured or delayed, as its presentation is similar to that of infantile neuromuscular disorders. We report the first Korean
case of infant botulism in an acute progressive floppy infant with poor sucking and a weak cry. No abnormalities were found in all blood, cerebrospinal fluid, genetic test, nerve conduction study, and imaging studies. A stool-toxin test was finally performed under suspicion of infant botulism, and the result was positive. The patient was immediately treated with heptavalent botulism antitoxin. Follow-up after 3 months showed normal development with a complete resolution of all symptoms. Therefore, clinical suspicion of infant botulism, which is a treatable infantile neuromuscular disease, is essential for early diagnosis and prompt treatment in the differential diagnosis of a floppy infant.