从可再生资源中微生物生产中链长度脂肪酸（MCFA）在建立可持续和清洁的化学工业中变得越来越重要。这篇综述全面总结了从可再生资源生产微生物MCFA的最新进展。提供了有关使用各种可再生资源和其他支持MCFA生产的辅助途径的两种主要MCFA生产途径的详细信息，以帮助了解生物基MCFA生产的基本原理。此外,传统的和经过充分研究的MCFA生产商分为两类，天然和合成生产者，概述了它们在MCFA生产中的特点。此外，为实现迄今为止最高MCFAs产量而采用的各种工程策略与建议用于MCFA过量生产的关键酶一起展示。最后,讨论了未来的挑战和观点，以更有效地生产生物基MCFA生产。
Microbial production of medium chain length fatty acids (MCFAs) from renewable resources is becoming increasingly important in establishing a sustainable and clean chemical industry. This
review comprehensively summarizes current advances in microbial MCFA production from renewable resources. Detailed information is provided on two major MCFA production pathways using various renewable resources and other auxiliary pathways supporting MCFA production to help understand the fundamentals of bio-based MCFA production. In addition, conventional and well-studied MCFA producers are classified into two categories, natural and synthetic producers, and their characteristics on MCFA production are outlined. Moreover, various engineering strategies employed to achieve the highest MCFAs production up to date are showcased together with key enzymes suggested for MCFA overproduction. Finally, future challenges and perspectives are discussed towards more efficient production of bio-based MCFA production.
