肿瘤的发生和进展与能量代谢异常密切相关,能量代谢与葡萄糖有关,蛋白质和脂质。能量代谢的重编程是癌症的标志之一。作为能量代谢的一种形式,脂肪酸代谢包括脂肪酸摄取,从头合成和β-氧化。近年来,脂肪酸β-氧化异常在肿瘤中的作用已逐渐被认识到。线粒体三功能蛋白(MTP)在脂肪酸β氧化和HADH(两种亚型:α亚基,HADHA和β亚基,HADHB)是MTP的重要亚基。HADH参与2、3和4脂肪酸β-氧化的步骤。然而,目前尚无综述HADH在肿瘤中的具体作用。因此,本研究以HADH为主要指标,探讨几种类型肿瘤中脂肪酸β-氧化的变化。本综述总结了HADH在11个器官中的变化(大脑,口腔,食道,肝脏,胰腺,胃,结肠直肠,淋巴,肺,乳房,肾),上调和下调的作用以及HADH与预后的关系。总之,根据肿瘤的位置,HADH可以是抑制因子或启动子,这与预后评估密切相关。HADHA和HADHB在已知和相当的肿瘤中具有相似的预后作用。
Tumor occurrence and progression are closely associated with abnormal energy metabolism and energy metabolism associated with glucose, proteins and lipids. The reprogramming of energy metabolism is one of the hallmarks of cancer. As a form of energy metabolism, fatty acid metabolism includes fatty acid uptake, de novo synthesis and β‑oxidation. In recent years, the role of abnormal fatty acid β‑oxidation in tumors has gradually been recognized. Mitochondrial trifunctional protein (MTP) serves an important role in fatty acid β‑oxidation and HADH (two subtypes: α subunit, HADHA and β subunit, HADHB) are important subunits of MTP. HADH participates in the steps of 2, 3 and 4 fatty acid β‑oxidation. However, there is no
review summarizing the specific role of HADH in tumors. Therefore, the present study focused on HADH as the main indicator to explore the changes in fatty acid β‑oxidation in several types of tumors. The present
review summarized the changes in HADH in 11 organs (cerebrum, oral cavity, esophagus, liver, pancreas, stomach, colorectum, lymph, lung, breast, kidney), the effect of up‑ and downregulation and the relationship of HADH with prognosis. In summary, HADH can be either a suppressor or a promoter depending on where the tumor is located, which is closely associated with prognostic assessment. HADHA and HADHB have similar prognostic roles in known and comparable tumors.