体积软组织损失是一个紧迫的手术问题,并且由于明显的软组织损失,经常会导致患者的预后不佳。受损的重要结构,和污染。绵羊前胃基质(OFM)在软组织缺损的手术治疗中已证明临床成功,尤其是在受污染的田地里,并为在最终关闭之前立即覆盖暴露的重要结构提供了有效的选择。
■该回顾性试点病例系列(n=13个缺损)评估了OFM(移植物和/或微粒形式)在受污染的体积软组织缺损的外科治疗中的临床有效性。患者表现为明显的软组织损失,经常有暴露的内脏,肌腱,骨头,或者肌肉,并接受OFM治疗,作为其住院手术管理的一部分。所有患者至少有1个显著的合并症,有可能使他们的愈合轨迹复杂化。主要研究终点是达到100%肉芽组织覆盖率的时间(天),次要终点是任何与器械相关的术后并发症.
■共评估了10例接受手术重建的患者的13个体积软组织缺损。平均缺损年龄为3.5±5.6周,平均面积为217.3±77.9cm2。大多数缺陷有暴露的结构(85%),所有缺陷均为疾病控制和预防中心2级或更高。100%肉芽组织形成的平均时间为23.4±9.2天,产品应用中位数为1.0。13个缺损中的7个采用分期重建,其余的(13个中的6个)通过使用标准伤口护理方案的次要意图愈合。术后无重大感染或不良事件(平均随访,7.4±2.4周。).
■这个回顾性的试点案例系列建立在越来越多的证据上,证明OFM可以用来促进功能性,大污染体积软组织缺损中血管化良好的软组织。
UNASSIGNED: Volumetric soft tissue loss is an urgent surgical issue and can frequently lead to suboptimal outcomes for patients due to significant soft tissue loss, compromised vital structures, and contamination. Ovine forestomach matrix (OFM) has demonstrated clinical success in the surgical management of soft tissue defects, especially in contaminated fields, and provides an effective option for immediate coverage of exposed vital structures before definitive closure.
UNASSIGNED: This retrospective pilot
case series (n = 13 defects) evaluated the clinical effectiveness of OFM (graft and/or particulate formats) in the surgical management of contaminated volumetric soft tissue defects. Patients presented with significant soft tissue loss, often with exposed viscera, tendon, bone, or muscle, and were treated with OFM as part of their inpatient surgical management. All patients had at least 1 significant comorbidity with the potential to complicate their healing trajectory. The primary study endpoint was time to 100% granulation tissue coverage (days), and the secondary endpoint was any device-related postoperative complications.
UNASSIGNED: A total of 13 volumetric soft tissue defects were evaluated in 10 patients who underwent surgical reconstruction. Mean defect age was 3.5 ± 5.6 weeks, and mean area was 217.3 ± 77.9 cm2. Most defects had exposed structures (85%), and all defects were Centers for Disease Control and Prevention grade 2 or higher. Mean time to 100% granulation tissue formation was 23.4 ± 9.2 days, with a median product application of 1.0. Staged reconstruction was used in 7 of 13 defects, with the remainder (6 of 13) left to heal via secondary intention using standard wound care protocols. There were no major postoperative infections or adverse events (mean follow-up, 7.4 ± 2.4 weeks.).
UNASSIGNED: This retrospective pilot
case series builds on a growing body of evidence that OFM can be utilized to facilitate the formation of functional, well-vascularized soft tissue in large contaminated volumetric soft tissue defects.