胎肺发育是一个关键而复杂的过程,为产后呼吸健康奠定了基础。然而,在这个微妙的发育过程中中断会导致胎儿肺部发育障碍,影响新生儿结局,并可能影响成年后的健康结局。最近的研究揭示了胎儿肺部发育障碍与成人疾病发展之间的有趣关联。了解这些联系可以为健康和疾病的发展起源提供有价值的见解,为有针对性的预防措施和临床干预措施铺平道路。本文旨在全面探讨胎儿肺部发育障碍与成人疾病的关系。我们深入研究胎儿肺发育阶段,检查影响胎儿肺成熟的关键因素。随后,我们调查特定的胎儿肺部发育障碍,如呼吸窘迫综合征(RDS),支气管肺发育不良(BPD),先天性膈疝(CDH),和其他异常。此外,我们探索这些关联背后的潜在机制,考虑到表观遗传修饰的作用,跨代效应,和宫内环境因素。此外,我们研究了将胎儿肺部发育障碍与成人呼吸系统疾病联系起来的流行病学证据和临床发现,包括哮喘,慢性阻塞性肺疾病(COPD),和其他呼吸道疾病。这篇综述为医疗保健专业人员和研究人员提供了宝贵的见解,指导未来的调查和制定战略的预防性干预和长期护理。
Fetal lung development is a crucial and complex process that lays the groundwork for postnatal respiratory health. However, disruptions in this delicate developmental journey can lead to fetal lung development disorders, impacting neonatal outcomes and potentially influencing health outcomes well into adulthood. Recent research has shed light on the intriguing association between fetal lung development disorders and the development of adult diseases. Understanding these links can provide valuable insights into the developmental origins of health and disease, paving the way for targeted preventive measures and clinical interventions. This
review article aims to comprehensively explore the association of fetal lung development disorders with adult diseases. We delve into the stages of fetal lung development, examining key factors influencing fetal lung maturation. Subsequently, we investigate specific fetal lung development disorders, such as respiratory distress syndrome (RDS), bronchopulmonary dysplasia (BPD), congenital diaphragmatic hernia (CDH), and other abnormalities. Furthermore, we explore the potential mechanisms underlying these associations, considering the role of epigenetic modifications, transgenerational effects, and intrauterine environmental factors. Additionally, we examine the epidemiological evidence and clinical findings linking fetal lung development disorders to adult respiratory diseases, including asthma, chronic obstructive pulmonary disease (COPD), and other respiratory ailments. This
review provides valuable insights for healthcare professionals and researchers, guiding future investigations and shaping strategies for preventive interventions and long-term care.