目的:益生菌似乎通过抑制幽门螺杆菌的作用改善幽门螺杆菌相关性消化不良;然而,关于它们对幽门螺杆菌未感染个体的影响存在不确定性。我们评估了加氏乳杆菌OLL2716(L.gasseriOLL2716)对未感染幽门螺杆菌的功能性消化不良(FD)个体。
方法:双盲,平行组,安慰剂对照,随机化,进行了对照试验。参与者被随机分配摄入含有L.gasseriOLL2716的酸奶(L.gasseriOLL2716组)或不含L.gasseriOLL2716的酸奶(安慰剂组),为期12周。参与者完成了涉及全球评估以及症状严重程度的问卷。根据事先准备的计划评估符合方案(PP)群体的功效。
结果:对116名个体进行了随机化;PP人群由106名个体组成(平均年龄42.8±9.0)。与安慰剂组相比,L.gasseriOLL2716组中对胃症状的总体影响的印象更为积极(统计趋势;p=0.073)。安慰剂组和L.gasseriOLL2716组主要FD症状的消除率分别为17.3%和35.3%(p=0.048)。
结论:L.gasseriOLL2716对没有幽门螺杆菌参与的FD具有有益作用。
OBJECTIVE: Probiotics appear to improve Helicobacter pylori-associated dyspepsia via an inhibitory effect on H. pylori; however, uncertainty exists regarding their effects in H. pylori-uninfected individuals. We evaluated the efficacy of Lactobacillus gasseri OLL2716 (L. gasseri OLL2716) on H. pylori-uninfected individuals with functional dyspepsia (FD).
METHODS: A double-blind, parallel-group, placebo-controlled, randomized, controlled
trial was performed. Participants were randomly assigned to ingest L. gasseri OLL2716-containing yogurt (L. gasseri OLL2716 group) or L. gasseri OLL2716-free yogurt (placebo group) for 12 weeks. Participants completed questionnaires that dealt with a global assessment as well as symptom severity. The per-protocol (PP) population was evaluated for efficacy in accordance with a plan prepared beforehand.
RESULTS: Randomization was performed on 116 individuals; the PP population consisted of 106 individuals (mean age 42.8 ± 9.0). The impressions regarding the overall effect on gastric symptoms were more positive in the L. gasseri OLL2716 group compared to that in the placebo group (statistical trend; p = 0.073). The elimination rate for major FD symptoms was 17.3 and 35.3% in the placebo and L. gasseri OLL2716 groups respectively (p = 0.048).
CONCLUSIONS: L. gasseri OLL2716 has beneficial effects on FD without H. pylori involvement.