角质层(SC)中应激反应的生物标志物的检测可用作对早期应激症状的客观评估和对卫生保健工作者(HCWs)中的减压干预的监测。
■这项研究的目的是探索免疫和激素反应以及皮肤屏障的SC生物标志物,以评估HCW中的心理困扰(PD)。
■25名女性HCWs和25名非HCWs参加。在基线和3-5天后(T1)使用胶带收集SC样品。我们分析了24种生物标志物(免疫学,血管,荷尔蒙,和天然保湿因子)。使用哥本哈根社会心理问卷的三个量表评估压力症状。这项研究涉及:确定SC生物标志物,将基线和T1时的应激症状和生物标志物相关联,使用Mann-Whitney检验检查组间的应激症状,使用普通最小回归比较各组之间的应激症状和生物标志物,并使用Wilcoxon符号秩调查基线和T1时SC生物标志物的时间变异性。
■鉴定了14种SC生物标志物。我们发现基线时的一般压力和“IL18”(r=0.55)物理压力和“IL1b”(r=0.36)以及认知压力和“MIP3a”(r=0.38)与一般压力和皮质醇(r=-0.49)之间存在相关性,T1时的物理压力和皮质醇(r=-0.60)和可的松(r=-0.67)。我们发现两组之间的压力症状和生物标志物没有差异,基线时的“MIP3a”除外。发现了两个时间点之间的生物标志物水平差异,\"\"VEGFA,\"\"ILRA,\"\"IL1RA/IL1a,\"\"NMF,\"和\"DHEA。\"
■SC可以是评估与免疫反应相关的生物标志物的合适生物材料,荷尔蒙反应,和皮肤屏障功能。SC生物标志物,表现出坚强,与压力症状的中度和弱相关性。值得注意的是,这些关联包括先天免疫的细胞因子和众所周知的应激激素,皮质醇和可的松.
UNASSIGNED: The detection of biomarkers of a stress response in the stratum corneum (SC) could be used as objective assessment of early stress symptoms and monitoring of stress reduction interventions in health care workers (HCWs).
UNASSIGNED: The aim of this
study is to explore SC biomarkers of immune and hormonal response and skin barrier for assessment of psychological distress (PD) in HCWs.
UNASSIGNED: Twenty-five female HCWs and 25 non-HCWs participated. SC samples were collected using adhesive tapes at baseline and 3-5 days later (T1). We analyzed 24 biomarkers (immunological, vascular, hormones, and natural moisturizing factors). Stress symptoms were assessed using three scales of Copenhagen Psychosocial Questionnaire. The
study involved: identifying SC biomarkers, correlating stress symptoms and biomarkers at baseline and T1, examining stress symptoms between the groups with a Mann-Whitney test, comparing stress symptoms and biomarkers between groups using Ordinary Least Regression and investigating temporal variability of SC biomarkers at baseline and T1 using a Wilcoxon-signed rank.
UNASSIGNED: Fourteen SC biomarkers were identified. We found correlations between general stress and \"IL18\" (r = 0.55) physical stress and \"IL1b\" (r = 0.36) and cognitive stress and \"MIP3a\" (r = 0.38) at baseline and general stress and cortisol (r = -0.49), physical stress and cortisol (r = -0.60) and cortisone (r = -0.67) at T1. We found no differences in stress symptoms and biomarkers between the groups, except for \"MIP3a\" at baseline. Differences in the biomarker levels between two time points were found for \"TARC,\" \"VEGFA,\" \"ILRA,\" \"IL1RA/IL1a,\" \"NMF,\" and \"DHEA.\"
UNASSIGNED: The SC can be suitable biological material to assess biomarkers related to immune response, hormonal response, and skin barrier function. The SC biomarkers, showed strong, moderate and weak correlations with stress symptoms. Notably, these associations include cytokines of innate immunity and well-known stress hormones, cortisol and cortisone.