乳酸性酸中毒很常见,最常伴有酸碱平衡紊乱。很少,它可能是危及生命的药物副作用。因此,早期确定乳酸性酸中毒的病因对于选择正确的治疗干预措施至关重要。虽然乳酸性酸中毒作为利奈唑胺的药物不良反应是公认的和有记录的临床实体,据我们所知,这种模拟急性颅内出血的发生尚未报道。下面的情况作为这种情况的一个例子给出。一名67岁的妇女因嗜睡而被送往急诊科,恶心和晕厥。头部CT未显示任何出血或肿块效应,但是实验室结果对乳酸升高有重要意义。病人最近接受了左全髋关节置换手术,并发耐甲氧西林金黄色葡萄球菌(MRSA)感染。她接受了6周的口服利奈唑胺治疗。在了解了她历史的关键部分后,利奈唑胺停药.她的乳酸迅速恢复正常,出院回家。一些出版物证明利奈唑胺通过破坏关键的线粒体功能来诱导乳酸性酸中毒。临床医生必须意识到利奈唑胺可引起乳酸性酸中毒。And,重要的是,药物不良反应往往可以模仿常见疾病。如果不能及早识别,可能会出现不祥的临床后果。总之,如果乳酸性酸中毒的临床表现不常见,则应怀疑利奈唑胺,并将其纳入鉴别诊断。
Lactic acidosis is common and most often associated with disturbed acid-base balance. Rarely, it can be a life-threatening medication side effect. Hence, determining the etiology of lactic acidosis early in patients is paramount in choosing the correct therapeutic intervention. Although lactic acidosis as an adverse drug reaction of linezolid is a well-recognized and documented clinical entity, the occurrence of such mimicking an acute intracranial bleed has not been reported to our knowledge. The following
case is presented as an example of such an occurrence. A 67-year-old woman presented to the emergency department for lethargy, nausea and syncope. The head CT did not demonstrate any bleeding or mass effect, but lab results were significant for elevated lactic acid. The patient recently underwent left total hip replacement surgery, which was complicated by a methicillin-resistant Staphylococcus aureus (MRSA) infection. She received 6 weeks of oral linezolid therapy. And upon learning that key part of her history, the linezolid was discontinued. Her lactic acid rapidly normalized and she was discharged home. Several publications demonstrate that linezolid induces lactic acidosis by disrupting crucial mitochondrial functions. It is essential that clinicians are aware that linezolid can cause lactic acidosis. And, the important reminder is that adverse drug reactions can often mimic common diseases. If it is not recognized early, ominous clinical consequences may occur. In conclusion, linezolid should be suspected and included in the differential diagnosis if lactic acidosis exists with an uncommon clinical picture.