elective surgery

择期手术
  • 文章类型: Case Reports
    存在一些关于由于不正确的胸管插入导致的器官损伤和死亡的报告;但是,关于胸管穿透肝脏并到达下腔静脉的报道有限。
    一名79岁的男子在原医院更换右胸管后,因管子大量出血而出现夹管。该管通过右肝静脉从肝实质进入下腔静脉,并在15小时后被取出,因为他的血流动力学稳定。假性动脉瘤破裂需要在住院的第二天进一步经导管动脉栓塞,患者在第17天被转移回转诊医院。
    下腔静脉误插相关胸管引起的肝损伤可以通过择期手术治疗,以预期该管的填塞效果。然而,由于有再出血的危险,影像学随访是必要的手术后不久。
    UNASSIGNED: Several reports on organ injury and death due to incorrect chest tube insertion exist; however, reports on the chest tube penetrating the liver and reaching the inferior vena cava are limited.
    UNASSIGNED: A 79-year-old man presented with a clamped tube because of massive bleeding from the tube following right chest tube replacement in the hospital of origin. The tube entered the inferior vena cava from the hepatic parenchyma via the right hepatic vein and was removed 15 h later because his hemodynamics stabilized. A ruptured pseudoaneurysm necessitated further transcatheter arterial embolism on the second hospitalization day, and the patient was transferred back to the referring hospital on day 17.
    UNASSIGNED: Liver injury caused by an inferior vena cava misinsertion-associated chest tube can be treated with elective surgery in anticipation of the tube\'s tamponade effect. However, due to the risk of rebleeding, imaging follow-up is necessary soon after surgery.
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  • 文章类型: Journal Article
    目的:我们旨在研究Omicron变异感染对择期手术患者围手术期器官功能的影响。方法:选择2022年10月至2023年1月在我院行择期手术的5029例患者。其中,在2022年10月至2022年11月期间接受择期手术的患者将第1组(未感染Omicron变异体)视为对照组;在2022年12月至2023年1月期间接受择期手术的患者将第2组(Omicron变异体感染后1个月)视为实验组.我们进一步将患者分为两个亚组进行分析:肿瘤亚组和非肿瘤亚组。器官系统功能指标数据,包括凝血参数,肝功能,全血细胞计数(CBC),和肾功能,在手术前后收集。随后通过二元逻辑回归分析两组之间的差异。结果:与未感染患者组相比,在感染后一个月接受择期手术的Omicron变异型感染患者中观察到以下变化:凝血酶原活动度(PTa),凝血酶原时间(PT),纤维蛋白原,白蛋白/球蛋白,丙氨酸氨基转移酶(ALT),平均红细胞血红蛋白浓度(MCHC),血小板(PLT),和贫血增加AST/ALT,间接胆红素(IBILI),嗜酸性粒细胞,术前尿酸下降;肺部感染/肺炎和纤维蛋白原升高,而AST/ALT,球蛋白,总胆红素(TBIL),白细胞计数(WBC),术后尿酸下降。两组的死亡率和住院时间(LOS)没有显着差异。亚组分析显示单核细胞升高,PLT,和纤维蛋白原分类,水平和减少的球蛋白,前白蛋白(PBA),嗜酸性粒细胞,与未感染患者相比,在Omicron感染后一个月接受择期手术的患者的肿瘤亚组中的尿酸水平。与非肿瘤亚组相比,纤维蛋白原水平,肺部感染/肺炎,TBIL,未感染患者的PLT计数增加,而球蛋白和嗜酸性粒细胞水平下降。结论:与未感染患者相比,Omicron变异型感染后1个月接受择期手术的患者围手术期凝血参数变化最小,肝功能,CBC计数,和肾功能。此外,两组在术后死亡率或LOS方面无显著差异.
    Purpose: We aimed to investigate the impact of Omicron variant infection on the perioperative organ function in patients undergoing elective surgery. Methods: A total of 5029 patients who underwent elective surgery between October 2022 and January 2023 at our hospital were enrolled. Among them, the patients who underwent elective surgery between October 2022 and November 2022 composed Group 1 (not infected with the Omicron variant) the control group; those who underwent elective surgery between December 2022 and January 2023 composed Group 2 (one month after Omicron variant infection) the experimental group. We further divided the patients into two subgroups for analysis: the tumor subgroup and the nontumor subgroup. Data on organ system function indicators, including coagulation parameters, liver function, complete blood count (CBC), and kidney function, were collected before and after surgery. Differences between the two groups were subsequently analyzed via binary logistic regression analysis. Results: Compared with those in the uninfected patient group, the following changes were observed in patients with Omicron variant infection who underwent elective surgery one month after infection: prothrombin activity (PTa), prothrombin time (PT), fibrinogen, albumin/globulin, alanine aminotransferase (ALT), mean corpuscular hemoglobin concentration (MCHC), platelet (PLT), and anemia were increased AST/ALT, indirect bilirubin (IBILI), eosinophils, and uric acid were decreased before surgery; and lung infection/pneumonia and fibrinogen were increased, while AST/ALT, globulin, total bilirubin (TBIL), white blood cell count (WBC), and uric acid were decreased after surgery. There was no significant difference in the mortality rate or length of hospital stay (LOS) between the two groups. Subgroup analysis revealed elevated monocyte, PLT, and fibrinogen classification, levels and decreased globulin, prealbumin (PBA), eosinophil, and uric acid levels in the tumor subgroup of patients who underwent elective surgery one month after Omicron infection compared with those in the uninfected patients. Compared with the nontumor subgroup, fibrinogen levels, lung infection/pneumonia, TBIL, and PLT count were increased in the uninfected patients, while the globulin and eosinophil levels were decreased. Conclusion: Compared with uninfected patients, patients who underwent elective surgery one month after Omicron variant infection exhibited minimal changes in perioperative coagulation parameters, liver function, CBC counts, and kidney function. Additionally, no significant differences in postoperative mortality or LOS were observed between the two groups.
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  • 文章类型: Journal Article
    背景:择期手术病例的取消是常见的并且具有显著的负面后果。造成宝贵资源的浪费,病人不快乐,和患者的心理压力。尽管如此,对埃塞俄比亚手术当天的病例取消和相关因素知之甚少,特别是在研究领域。
    目的:本研究旨在评估Wolaita地区医院手术当天病例取消的程度和相关因素,南埃塞俄比亚,2023年5月17日至6月17日。
    方法:在WolaitaSodo地区进行了一项以医院为基础的横断面研究,涉及322名患者,南埃塞俄比亚。包括在研究期间安排的所有择期手术病例。使用系统随机抽样过程选择参与者的全部数量。EpidataV.3用于输入数据,并采用SPSSV.25进行分析。二元逻辑回归用于检查可能的关联。在多变量分析中使用P值<0.05和95%CI作为显著统计学关联的阈值。
    结果:在研究期间,总共有313名研究参与者被安排进行选择性外科手术,反应率为97.2%。研究参与者的平均(±SD)年龄为39.18(±10.64)岁。三分之二的病人,53名(64%)是农村居民,超过一半(178人,55.3%)的参与者是女性。这一发现表明,病例取消率为22.4%(95%CI:19.3-25.9%)。在全部取消的案件中,男性49人(58.3%)。农村住宅等变量(AOR=3.4895%CI:1.22-9.95),缺乏实验室结果(AOR=2.33,95CI:1.20-4.51),眼科.(AOR=2.5395%CI:1.52-4.49),HTN(AOR=2.53,95%CI:1.52-4.49),患者拒绝(AOR=3.0195%CI:1.22-5.05),年龄b/n31和43(AOR=1.50,95%CI:1.02-2.01)是取消择期手术病例的显着相关因素。
    结论:在这项研究中,病例取消的时间表很高。案件取消的促成因素是农村居民,缺乏实验室结果,眼科,HTN,病人拒绝,和年龄。为了减少不必要的取消并提高成本效率,医院管理和医务人员必须仔细计划,有效沟通,有效利用医院资源。
    BACKGROUND: Cancellations of elective surgery cases are frequent and have significant negative consequences. It causes wasting of valuable resources, patient unhappiness, and psychological stress of patients. Despite this, little is known about the case cancellation and associated factors on the day of surgery in Ethiopia, particularly in the study area.
    OBJECTIVE: This study aimed to assess the magnitude of case cancellation and associated factors on the day of surgery in hospitals in Wolaita zone, South Ethiopia, from May 17 to June 17, 2023.
    METHODS: A hospital-based cross-sectional study involving 322 patients was conducted at Wolaita Sodo Zone, South Ethiopia. All elective surgical cases scheduled during the study period were included. The entire number of participants was selected using a systematic random sampling process. Epidata V.3 was used to enter data, and SPSS V.25 was used to analyze it. Binary logistic regression was used to check for a possible association. P-values < 0.05 and 95% CI were used on multi-variable analysis as the threshold for the significant statistical association.
    RESULTS: A total of 313 study participants were scheduled for elective surgical procedures during the study period and gave a response rate of 97.2%. The mean (± SD) age of the study participants was 39.18 (± 10.64) years. The two-third of patients, 53(64%) were rural residents, and more than half (178, or 55.3%) of the participants were female. This finding showed that the case cancellation was 22.4% (95% CI: 19.3 -25.9%). Among the total canceled cases, 49(58.3%) were males. Variables like rural residence (AOR = 3.48 95% CI: 1.22-9.95), Lack of lab result (AOR = 2.33, 95%CI:1.20-4.51), ophthalmology dept. (AOR = 2.53 95% CI:1.52-4.49), HTN (AOR = 2.53, 95% CI:1.52-4.49), patient refusal (AOR = 3.01 95% CI:1.22-5.05), and age b/n 31 and 43 (AOR = 1.50, 95% CI:1.02-2.01) were significantly associated factors with cancellation of elective surgical cases.
    CONCLUSIONS: In this study schedule of case cancellation was high. The contributing factors of case cancellation were rural residence, Lack of lab results, ophthalmology dept, HTN, patient refusal, and age. To decrease unnecessary cancellations and increase cost efficiency, hospital administration and medical staff must plan ahead carefully, communicate effectively, and make efficient use of hospital resources.
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  • 文章类型: Journal Article
    背景:本研究的目的是调查接受子宫内膜瘤择期手术的女性中先前自发性卵巢子宫内膜瘤破裂的比例和临床特征。
    方法:本回顾性研究基于2017年1月至2022年10月在北京协和医院由同一妇科团队进行的子宫内膜瘤择期手术队列。在选择性手术期间诊断为先前自发性子宫内膜瘤破裂的患者被纳入破裂组。在同一个队列中,选择同期治疗的未破裂子宫内膜瘤患者作为未破裂组,按年龄1:2配对.收集并比较两组人口统计学和临床资料。
    结果:队列中共422例患者被诊断为子宫内膜瘤。破裂组38例(9.0%),未破裂组76例。所有参与者均接受腹腔镜手术治疗。在破裂组中,86.8%的患者有急性腹痛病史,未破裂组仅为13.2%(P<0.001)。与未破裂组相比,诊断为子宫内膜瘤破裂的患者的BMI较低(P=0.021),子宫内膜瘤的最大直径较大(P=0.040),盲囊部分闭塞而不是完全闭塞的比例更高(P=0.003)。
    结论:子宫内膜瘤自发破裂并不罕见。我们研究中子宫内膜瘤自发性破裂的比例高于文献报道的比例。在患有子宫内膜瘤的女性中,急性腹痛的发作应视为囊肿破裂,尤其是大囊肿患者.
    BACKGROUND: The aim of the study is to investigate the proportion and clinical features of previous spontaneously ruptured ovarian endometrioma among women who underwent elective surgery for endometrioma.
    METHODS: This retrospective study was based on a cohort of elective surgeries for endometrioma performed by the same gynecologic team at Peking Union Medical College Hospital from January 2017 to October 2022. Patients diagnosed with previous spontaneously ruptured endometrioma during elective surgery were enrolled in the ruptured group. In the same cohort, patients with unruptured endometrioma treated during the same period were selected as the unruptured group by 1:2 matching according to age. Demographic and clinical information were collected and compared between two groups.
    RESULTS: A total of 422 patients in the cohort were diagnosed with endometrioma. There were 38 patients (9.0%) in ruptured group and 76 patients in unruptured group. All enrolled participants were treated by laparoscopic surgery. In ruptured group, 86.8% patients had a history of acute abdominal pain, which was only 13.2% in unruptured group (P < 0.001). Compared to unruptured group, patients diagnosed with ruptured endometrioma had a lower BMI (P = 0.021), larger maximum diameter of endometrioma (P = 0.040), higher proportion of cul-de-sac partial obliteration rather than complete obliteration (P = 0.003).
    CONCLUSIONS: Spontaneous rupture of endometrioma is not rare. The proportion of spontaneous rupture of endometrioma in our study was higher than that reported in the literatures. In women with endometrioma, the onset of acute abdominal pain should be considered a rupture of cyst, especially in patients with big cysts.
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  • 文章类型: Journal Article
    已知很少有干预措施可以降低选择性手术后发生的呼吸衰竭(术后呼吸衰竭;PRF)的发生率。我们以前曾报道过在择期手术后的前5天内发生的与PRF相关的危险因素(早期PRF;E-PRF);然而,在择期手术后6天或更多天发生的PRF(晚期PRF;L-PRF)可能代表不同的实体。我们假设与E-PRF相比,L-PRF与更差的结果和不同的危险因素相关。
    这是一项回顾性配对病例对照研究,纳入了2012年10月至2015年9月在加州大学五个学术医疗中心之一接受非心脏和非肺外科手术的59,073名连续成年患者。我们确定了L-PRF患者,由外科医生和重症医师主题专家审查确认,并将他们与根据医院没有发展PRF(No-PRF)的患者进行1:1匹配,年龄,和外科手术。然后,我们分析了与L-PRF和E-PRF和No-PRF相关的风险因素和结果。
    在95例L-PRF患者中,50.5%是女性,71.6%白色,27.4%的西班牙裔,53.7%的医疗保险接受者;中位年龄为63岁(IQR56,70)。与95名无PRF患者和319名发生E-PRF的患者相比,L-PRF与较高的发病率和死亡率相关,住院和重症监护病房的时间更长,和增加的成本。与无PRF相比,与L-PRF相关的因素包括:先发神经系统疾病(OR4.36,95%CI1.81-10.46),每小时麻醉持续时间(OR1.22,95%CI1.04-1.44),和最大术中峰值吸气压力/cmH20(OR1.14,95%CI1.06-1.22)。
    我们发现预先存在的神经系统疾病,麻醉持续时间较长,术中最大吸气峰压升高与成年患者择期手术后6天或更长时间发生呼吸衰竭相关(L-PRF).针对这些因素的干预措施可能值得未来评估。
    Few interventions are known to reduce the incidence of respiratory failure that occurs following elective surgery (postoperative respiratory failure; PRF). We previously reported risk factors associated with PRF that occurs within the first 5 days after elective surgery (early PRF; E-PRF); however, PRF that occurs six or more days after elective surgery (late PRF; L-PRF) likely represents a different entity. We hypothesized that L-PRF would be associated with worse outcomes and different risk factors than E-PRF.
    This was a retrospective matched case-control study of 59,073 consecutive adult patients admitted for elective non-cardiac and non-pulmonary surgical procedures at one of five University of California academic medical centers between October 2012 and September 2015. We identified patients with L-PRF, confirmed by surgeon and intensivist subject matter expert review, and matched them 1:1 to patients who did not develop PRF (No-PRF) based on hospital, age, and surgical procedure. We then analyzed risk factors and outcomes associated with L-PRF compared to E-PRF and No-PRF.
    Among 95 patients with L-PRF, 50.5% were female, 71.6% white, 27.4% Hispanic, and 53.7% Medicare recipients; the median age was 63 years (IQR 56, 70). Compared to 95 matched patients with No-PRF and 319 patients who developed E-PRF, L-PRF was associated with higher morbidity and mortality, longer hospital and intensive care unit length of stay, and increased costs. Compared to No-PRF, factors associated with L-PRF included: preexisiting neurologic disease (OR 4.36, 95% CI 1.81-10.46), anesthesia duration per hour (OR 1.22, 95% CI 1.04-1.44), and maximum intraoperative peak inspiratory pressure per cm H20 (OR 1.14, 95% CI 1.06-1.22).
    We identified that pre-existing neurologic disease, longer duration of anesthesia, and greater maximum intraoperative peak inspiratory pressures were associated with respiratory failure that developed six or more days after elective surgery in adult patients (L-PRF). Interventions targeting these factors may be worthy of future evaluation.
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  • 文章类型: Journal Article
    背景:就美国医院的手术量而言,全肩关节置换术(TSA)是增长最快的手术之一。2020年,由于SARS-CoV-2(COVID-19)大流行,全国范围内的择期手术被暂停,大流行后的使用趋势尚未得到实质性评估。在全国范围内减少TSA的病例量是未知的;因此,这项研究的目的是比较患者的人口统计学,并发症,以及美国2019日历年(疫情前期)至2020年选择性TSA病例量的时间趋势。
    方法:使用多中心,从2019年至2020年的全国代表性样本,对所有接受选择性TSA的患者进行了回顾性查询。将COVID前(2019年和2020年第一季度)接受手术的患者与COVID期间(2020年第二季度至第四季度)的患者进行比较。在时间范围之间比较了案件卷的时间趋势。使用TSA,患者人口统计学,并发症,和住院时间进行了比较。线性回归用于评估研究期间病例体积的变化。使用P<0.05的统计学显著性阈值。
    结果:总计,在2019年(n=5342)和2020年(n=4325),有9667例患者接受了选择性TSA。2020年接受门诊TSA的患者比例明显高于前一年(20.6%vs.13.9%;P<.001)。总的来说,2019年至2020年,选择性TSA案件量下降了19.0%。2019年第一季度(n=1401)到2020年第一季度(n=1296)的病例量没有显着差异(P=.216)。然而,2020年第二季度,TSA选修量下降了54.6%。选择的TSA病例数量在2020年第三季度和2020年第四季度恢复到流行病前基线。2020年的平均停留时间与2019年(1.29vs.1.32天;P=.371),从2019年到2020年,每季度同日出院的比例都在增加(从年度病例的11.8%增加到26.8%)。2019年的总并发症发生率(4.6%)与2020年(4.9%)(P=.441)。
    结论:使用全国范围的样本,选修TSA在2020年第二季度急剧下降。2020年接受选择性TSA的患者的人口统计学在共病负担方面相似。大部分手术都过渡到门诊,尽管总体并发症发生率没有变化,但当天出院率在研究期间翻了一番。
    BACKGROUND: Total shoulder arthroplasty (TSA) is one of the fastest growing procedures in terms of volume performed in hospitals in the United States. In 2020, elective surgery was suspended nationwide as a result of the SARS-CoV-2 (COVID-19) pandemic, and the use trends in the wake of the pandemic have yet to be evaluated substantially. Nationwide case volume reduction for TSA is unknown; therefore, the aim of this study is to compare patient demographics, complications, and temporal trends in case volume of elective TSA in the calendar year 2019 (prepandemic) to 2020 in the United States.
    METHODS: Using a multicenter, nationwide representative sample from 2019 to 2020, a retrospective query was conducted for all patients undergoing elective TSA. Patients undergoing surgery pre-COVID (2019 and 2020 Q1) were compared to those during COVID (2020 Q2-Q4). Temporal trends in case volumes were compared between time frames. TSA use, patient demographics, complications, and length of stay were compared between years. Linear regression was used to evaluate for changes in the case volume over the study period. A statistical significance threshold of P <.05 was used.
    RESULTS: In total, 9667 patients underwent elective TSA in 2019 (n = 5342) and 2020 (n = 4325). The proportion of patients who underwent outpatient TSA in 2020 was significantly greater than the year prior (20.6% vs. 13.9%; P < .001). Overall, elective TSA case volume declined by 19.0% from 2019 to 2020. There was no significant difference in the volume of cases in 2019 Q1 (n = 1401) through 2020 Q1 (n = 1296) (P = .216). However, elective TSA volumes declined by 54.6% in 2020 Q2. Elective TSA case volumes recovered to prepandemic baseline in 2020 Q3 and 2020 Q4. The average length of stay was comparable in 2020 vs. 2019 (1.29 vs. 1.32 days; P = .371), with the proportion of same-day discharge increasing per quarter from 2019 to 2020 (from 11.8% to 26.8% of annual cases). There was no significant difference in the total complication rates in 2019 (4.6%) vs. 2020 (4.9%) (P = .441).
    CONCLUSIONS: Using a nationwide sample, elective TSA precipitously declined during the second quarter of 2020. Patient demographics of those undergoing elective TSA in 2020 were similar in comorbidity burden. A large proportion of surgeries were transitioned to the outpatient setting, with rates of same-day discharge doubling over the study period despite no change in overall complication rates.
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  • 文章类型: Journal Article
    BACKGROUND: Emergency appendectomy is often performed for de Garengeot hernia. However, in some cases, there may be a chance to perform an appendix-preserving elective surgery.
    METHODS: A 76-year-old woman presented to our hospital with complaints of a right inguinal swelling, which we diagnosed as a de Garengeot hernia using computed tomography (CT). B-mode ultrasonography (US) of the mass showed an appendix 4-6 mm in diameter with a clear wall structure; color Doppler US showed pulsatile blood flow signal in the appendiceal wall. Twenty-eight days later, herniorrhaphy with transabdominal preperitoneal repair (TAPP) was performed without appendectomy. Another 70-year-old woman presented to our hospital with complaints of a painful bulge in the right inguinal region. The diagnosis of de Garengeot hernia was made using CT. B-mode US showed an appendix 5 mm in diameter with a clear wall structure. Color Doppler US showed a pulsatile blood signal in the appendiceal wall. Seven days later, herniorrhaphy with TAPP was performed without appendectomy.
    CONCLUSIONS: De Garengeot hernia is often associated with appendicitis; however, an appendix-preserving elective herniorrhaphy can be performed if US and intraoperative findings do not suggest appendicitis or circulatory compromise in the appendix.
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  • 文章类型: Journal Article
    Since the 1980s, the international literature has reported variations for healthcare services, especially for elective ones. Variations are positive if they reflect patient preferences, while if they do not, they are unwarranted, and thus avoidable. Benign hysterectomy is among the most frequent elective surgical procedures in developed countries, and, in recent years, it has been increasingly delivered through minimally invasive surgical techniques, namely laparoscopic or robotic. The question therefore arises over what the impact of these new surgical techniques on avoidable variation is. In this study we analyze the extent of unwarranted geographical variation of treatment rates and of the adoption of minimally invasive procedures for benign hysterectomy in an Italian regional healthcare system. We assess the impact of the surgical approach on the provision of benign hysterectomy, in terms of efficiency (by measuring the average length of stay) and efficacy (by measuring the post-operative complications). Geographical variation was observed among regional health districts for treatment rates and waiting times. At a provider level, we found differences for the minimally invasive approach. We found a positive and significant association between rates and the percentage of minimally invasive procedures. Providers that frequently adopt minimally invasive procedures have shorter average length of stay, and when they also perform open hysterectomies, fewer complications.
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  • 文章类型: Journal Article
    OBJECTIVE: Renal-transplanted patients are reported to have a high anastomotic leakage (AL) rate after colorectal surgery. We aimed to define AL-related morbidity and mortality rates after elective left colectomy in renal-transplanted patients.
    METHODS: Data were prospectively collected between 2010 and 2015 from patients who underwent elective left colectomy with supra-peritoneal anastomosis in a single French referral hospital. We compared AL rate, and morbidity and mortality rates between renal-transplanted patients and controls.
    RESULTS: We identified 120 patients who underwent elective left colectomy during the study period. We retrospectively divided this cohort into 20 (17%) kidney-transplanted recipients (KTR-group) and the remaining 100 patients comprised the control group (C-group). There were no significant differences in sex, age, ASA score, body mass index, history of abdominal surgery and benign/malignant disease ratio between the KTR-group and the C-group. The AL rate was approximately four times higher in the KTR-group versus the C-group (25% vs 7%, p = 0.028). Intra-abdominal septic complications (p = 0.0005) and reoperation rates (p = 0.025) were also higher in the KTR-group. The laparoscopic approach was performed less in the KTR-group (35% versus 93%, p < 0.0001).
    CONCLUSIONS: Renal transplantation was identified as a risk factor of AL following elective left colectomy, as well as increased intra-abdominal septic morbidity and higher reoperation rate. Further multicentric studies are required to identify potential independent risk factors of AL after colorectal surgery in these frail populations.
    BACKGROUND: The present study was declared on ClinicalTrials.gov (ID: NCT04495023).
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  • 文章类型: Journal Article
    术后呼吸衰竭是术后最常见的严重肺部并发症,然而,对可以降低其发病率的因素知之甚少。我们试图阐明与择期手术后的前5天内发生的呼吸衰竭相关的可改变因素。
    2012年10月1日至2015年9月30日期间在五个学术医疗中心进行手术的成年人的匹配病例对照研究。病例使用管理数据进行识别,并通过重症监护临床医生的图表审查进行确认。对照组与基于医院的病例1:1匹配,年龄,和外科手术。
    我们的总样本(n=638)为56.4%的女性,71.3%白色,年龄中位数为62岁(四分位距51,70岁)。术后早期呼吸衰竭的相关因素包括男性(比值比[OR]1.72,95%置信区间[CI]1.12-2.63),美国麻醉医师协会III级或以上(OR2.85,95%CI1.74-4.66),先前存在的合并症数量更多(OR1.14,95%CI1.004-1.30),手术持续时间增加(OR1.14,95%CI1.06-1.22),术中呼气末正压(OR1.23,95%CI1.13-1.35)和潮气量(OR1.13,95%CI1.004-1.27)增加,24小时的净流体平衡更大(OR1.17,95%CI1.07-1.28)。
    我们发现更大的术中呼吸机容量和压力以及24小时液体平衡是与术后早期呼吸衰竭相关的潜在可改变因素。需要进一步的研究来独立验证这些风险因素,探讨其在术后早期呼吸衰竭发展中的作用,并可能评估有针对性的干预措施。
    Postoperative respiratory failure is the most common serious postoperative pulmonary complication, yet little is known about factors that can reduce its incidence. We sought to elucidate modifiable factors associated with respiratory failure that developed within the first 5 d after an elective operation.
    Matched case-control study of adults who had an operation at five academic medical centers between October 1, 2012 and September 30, 2015. Cases were identified using administrative data and confirmed via chart review by critical care clinicians. Controls were matched 1:1 to cases based on hospital, age, and surgical procedure.
    Our total sample (n = 638) was 56.4% female, 71.3% white, and had a median age of 62 y (interquartile range 51, 70). Factors associated with early postoperative respiratory failure included male gender (odds ratio [OR] 1.72, 95% confidence interval [CI] 1.12-2.63), American Society of Anesthesiologists class III or greater (OR 2.85, 95% CI 1.74-4.66), greater number of preexisting comorbidities (OR 1.14, 95% CI 1.004-1.30), increased operative duration (OR 1.14, 95% CI 1.06-1.22), increased intraoperative positive end-expiratory pressure (OR 1.23, 95% CI 1.13-1.35) and tidal volume (OR 1.13, 95% CI 1.004-1.27), and greater net fluid balance at 24 h (OR 1.17, 95% CI 1.07-1.28).
    We found greater intraoperative ventilator volume and pressure and 24-h fluid balance to be potentially modifiable factors associated with developing early postoperative respiratory failure. Further studies are warranted to independently verify these risk factors, explore their role in development of early postoperative respiratory failure, and potentially evaluate targeted interventions.
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