缺乏关于发育胚胎的第一细胞谱系的分子表征的广泛综述研究，特别是对于导致细胞命运确定的最早分化过程中的主要事件。这里,我们根据PRISMA指南进行了系统评价和荟萃分析.在2021年4月之前，根据既定的搜索策略搜索了MEDLINE-PubMed。对符合纳入标准的36项研究进行了定性和定量分析。在研究中，50%（18/36）使用小鼠作为动物模型，22.2%(8/36)猪,16.7%（6/36）牛，5.5%（2/36）人类，2.8%(1/36)的山羊和2.8%(1/36)的马。我们的结果表明，胚胎的每个第一细胞谱系都需要一定的表达模式来建立命运的细胞决定。此外，这些模式被许多物种共有，特别是对于那些已经在文献中被鉴定为生物标志物的分子。总之,本研究整合了精心选择的有关哺乳动物胚胎发育和第一细胞决定的研究，并总结了有关第一细胞谱系的差异特征及其与特定基因表达的可能关系的信息。
A wide-ranging
review study regarding the molecular characterization of the first cell lineages of the developmental embryo is lacking, especially for the primary events during earliest differentiation which leads to the determination of cellular fate. Here, a systematic
review and meta-analysis were conducted according to PRISMA guidelines. MEDLINE-PubMed was searched based on an established search strategy through April 2021. Thirty-six studies fulfilling the inclusion criteria were subjected to qualitative and quantitative analysis. Among the studies, 50 % (18/36) used mice as an animal model, 22.2 % (8/36) pigs, 16.7 % (6/36) cattle, 5.5 % (2/36) humans, and 2.8 % (1/36) goats as well as 2.8 % (1/36) equine. Our results demonstrated that each of the first cell lineages of embryos requires a certain pattern of expression to establish the cellular determination of fate. Moreover, these patterns are shared by many species, particularly for those molecules that have already been identified in the literature as biomarkers. In conclusion, the present study integrated carefully chosen studies regarding embryonic development and first cellular decisions in mammalian species and summarized the information about the differential characterization of the first cell lineages and their possible relationship with specific gene expression.
