dysphagia

吞咽困难
  • 文章类型: Case Reports
    吞咽困难是创伤性脑损伤(TBI)后的常见并发症,这与营养不良的风险增加有关,肺炎,预后不良。在这篇文章中,我们介绍了1例TBI伴持续性吞咽困难的病例,用局灶性肌肉振动治疗。除了常规疗法外,还在舌骨上肌和舌头上施加了100Hz和50Hz的振动刺激(每天两次30分钟;每周五天;总共四周),以迅速恢复吞咽并避免永久性缺陷的可能性。总之,该病例突出了一种治疗TBI持续性吞咽困难的新方法,这应该在吞咽困难的管理中考虑。
    Dysphagia is a common complication following traumatic brain injury (TBI), and it is related to an increased risk of malnutrition, pneumonia, and poor prognosis. In this article, we present a case of TBI with persistent dysphagia treated with focal muscle vibration. A 100 Hz and 50 Hz vibratory stimuli were applied over the suprahyoid muscles and tongue (30 min twice a day; five days a week; for a total of four weeks) in addition to the conventional therapy to quickly recover swallowing and avoid the possibility of permanent deficits. In conclusion, this case highlights a novel therapeutic approach for persistent dysphagia in TBI, which should be considered in the management of dysphagia.
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  • 文章类型: Journal Article
    背景:由于如今患者往往有多种疾病和复杂的病史,我们的目标是识别高质量的,非工具性吞咽困难筛查工具用于在急性护理环境中检测所有疾病类别的成人吞咽困难病例。
    方法:从每个数据库最早成立到2021年7月31日,在五个数据库中进行了文献检索,并以五个关键词为指导:“吞咽困难”,\'吞咽\',\'筛选\',\'test\'和\'measure\'。在不限制搜索任何特定疾病类别的情况下,审核员对原始研究进行了评估,并确定了工具是否经过了仪器评估的验证,以及是否将其设计为通过-失败程序来筛查吞咽困难是否不存在或存在.我们进一步排除了任何工具,如果它是(1)用于儿科焦点,或(2)患者自我报告问卷。使用经修订的诊断准确性研究质量评估工具(QUADAS-2)对所有最终候选工具进行了方法学质量评估。
    结果:在195项研究中,确定了165种工具,20名候选工具接受了QUADAS-2审查。我们发现了六个高质量的,在急性护理环境中检测成人吞咽困难病例的非工具筛查工具,包括耶鲁燕子协议,狼吞虎咽的屏幕,多伦多床边吞咽筛查测试(英语和葡萄牙语版本),Sapienza全球床边评估吞咽和两步加厚水测试。这些高质量的工具主要是为中风患者开发的。最初只有耶鲁燕子方案对中风的异质人群进行了测试,多发性硬化症,创伤性脑损伤,食道手术,神经外科和头颈癌.
    结论:结果突出表明,在包括老年住院患者在内的几个出现的高危人群中,缺乏高质量吞咽困难筛查工具的差距,或气管内拔管后的患者。需要进一步的研究来确定这六种工具是否可以有效地应用于急性护理环境中的不同高危人群,以筛选病例发现。
    BACKGROUND: As patients nowadays tend to have multiple diseases and complex medical histories, our aim was to identify high-quality, non-instrumental dysphagia screening tools used for the detection of adult dysphagia cases in all disease categories in acute-care settings.
    METHODS: A literature search was conducted in five databases from each database\'s earliest inception to 31 July 2021 and guided by five keywords: \'dysphagia\', \'deglutition\', \'screening\', \'test\' and \'measure\'. Without limiting the search in any specific disease category, reviewers assessed original studies and identified tools if they had been validated against instrumental evaluations and if they had been designed as a pass-fail procedure to screen whether dysphagia is absent or present. We further excluded any tool if it was (1) for pediatric focus, or (2) a patient self-report questionnaire. All final tool candidates underwent a methodological quality appraisal using the Revised Tool for the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2).
    RESULTS: Out of 195 studies with 165 tools identified, 20 tool candidates underwent QUADAS-2 review. We found six high-quality, non-instrumental screening tools for detecting adult dysphagia cases in acute-care settings, including the Yale Swallow Protocol, Gugging Swallowing Screen, Toronto Bedside Swallowing Screening Test (both English and Portuguese versions), Sapienza Global Bedside Evaluation of Swallowing and Two-Step Thickened Water Test. These high-quality tools were developed primarily for patients with stroke. Only Yale Swallow Protocol was originally tested for heterogeneous populations with stroke, multiple sclerosis, traumatic brain injury, oesophageal surgery, neurosurgery and head-and-neck cancer.
    CONCLUSIONS: The results highlight the gap in the unavailability of high-quality dysphagia screening tool in several emerged high-risk populations including elderly inpatients, or patients following endotracheal extubation. Further research is needed to determine whether these six tools can be effectively applied across different high-risk populations in acute-care settings to screen for cases finding.
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  • 文章类型: Journal Article
    本研究旨在评估经导管胃化疗栓塞(GTC)联合全身化疗(SYS)与单用SYS治疗吞咽困难的有效性。改善晚期胃贲门癌(AGCC)患者的生活质量(QoL)和营养状况。使用2018年1月至2022年12月经历吞咽困难并单独使用SYS或SYS联合GTC的AGCC连续患者的数据进行回顾性审查。进行倾向评分匹配(PSM)分析以解决潜在的混杂因素。Ogilvie吞咽困难评分用于评估吞咽困难,癌症治疗功能评估-一般7(FACT-G7)用于评估QoL,患者主观综合评估(PG-SGA)用于评价营养状况.PSM之后,共有228名患者被纳入分析,每组114人。在初始治疗后4周和8周,GTC+SYS组的Ogilvie评分中位数显著低于SYS单独组(P<0.001).同样,初始治疗后4周,GTC+SYS组的PG-SGA评分中位数为2.0,单独SYS组为6.0.GTC+SYS组的FACT-G7评分中位数为13.0,而单用SYS组为10.5。这些差异在8周时仍然显著(P<0.001)。总之,在SYS中加入GTC可以更有效和及时地缓解吞咽困难,在出现吞咽困难的AGCC患者中,与单独使用SYS相比,改善营养状况并提高QoL。
    The present study aimed to assess the effectiveness of gastric transcatheter chemoembolization (GTC) combined with systemic chemotherapy (SYS) compared with SYS alone in managing dysphagia, and improving the quality of life (QoL) and nutritional status of patients with advanced gastric cardiac cancer (AGCC). A retrospective review was performed using data from consecutive patients with AGCC who experienced dysphagia and underwent either SYS alone or SYS combined with GTC from January 2018 to December 2022. Propensity score matching (PSM) analysis was performed to address potential confounding factors. Ogilvie dysphagia scores were used to assess dysphagia, the Functional Assessment of Cancer Therapy-General 7 (FACT-G7) was used to assess QoL, and the Patient-Generated Subjective Global Assessment (PG-SGA) was used to evaluate nutritional status. After PSM, a total of 228 patients were included in the analysis, with 114 in each group. At 4 and 8 weeks after the initial treatment, the GTC + SYS group demonstrated significantly lower median Ogilvie scores compared with the SYS alone group (P<0.001). Similarly, the median PG-SGA score at 4 weeks after the initial treatment was 2.0 in the GTC + SYS group and 6.0 in the SYS alone group. The median FACT-G7 scores in the GTC + SYS group was 13.0, compared with 10.5 in the SYS alone group. These differences remained significant at 8 weeks (P<0.001). In conclusion, the addition of GTC to SYS may more effectively and promptly relieve dysphagia, improve nutritional status and enhance QoL compared with SYS alone in patients with AGCC presenting with dysphagia.
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  • 文章类型: Case Reports
    肌萎缩侧索硬化症(ALS)是一种无法治愈的罕见神经退行性疾病,45%的病例表现出吞咽困难的症状;其临床症状是萎缩,弱点,和面部肌肉的肌束,舌头,和咽部。此外,吞咽困难是吸入性肺炎的主要原因。吞咽困难的传统治疗方法因患者的吞咽困难而异。初始阶段包括饮食一致性调整,进展为替代如鼻胃管或经皮内镜胃造瘘术(PEG)在晚期阶段。整骨疗法(OMT)是一种补充的“动手”方法,已在各种健康状况下作为附加疗法显示出积极的结果。这项研究是一个被诊断患有ALS并伴有吞咽困难的男性的病例报告,使用非常包括OMT的协议进行管理。患者在纵隔区域表现出躯体功能障碍,上颈部,和枕骨区域在解剖学上都与神经系统相关,尤其是舌咽反射.在康复方案结束时,用StrandScale和吞咽测试测量的吞咽问题减少了,患者报告用肌萎缩侧索硬化评估问卷(ALSAQ-40)评估的心理-身体健康状况改善.相反,用ALSFRS-S测量的神经功能保持稳定。尽管这项研究设计的性质阻止了任何因果假设,阳性结果应导致未来的随机对照试验,以评估OMT作为改善ALS患者健康的辅助治疗方案的有效性.
    Amyotrophic lateral sclerosis (ALS) is an incurable rare neurodegenerative condition, with 45% of cases showing the symptom of dysphagia; its clinical signs are atrophy, weakness, and fasciculations of the facial muscles, tongue, and pharynx. Furthermore, dysphagia is the main cause of aspiration pneumonia. The traditional treatment for dysphagia varies based on the patient\'s difficulty of swallowing. The initial phase consists of dietary consistency adjustments, progressing to alternatives like nasogastric tubes or percutaneous endoscopic gastrostomy (PEG) in advanced stages. Osteopathic manipulative treatment (OMT) is a complementary \'hands-on\' approach that has already shown positive results as an add-on therapy in various health conditions. This study is a case report of a man diagnosed with ALS with initial dysphagia, managed with a protocol that extraordinarily included OMT. The patient showed somatic dysfunctions in the mediastinal region, upper cervical region, and occipital area which are all anatomically related to the nervous system, especially the glossopharyngeal reflex. At the end of the rehabilitation protocol, there was a reduction in the swallowing problems measured with Strand Scale and swallowing tests, and the patient reported an improved psycho-physical well-being assessed with the Amyotrophic Lateral Sclerosis Assessment Questionnaire (ALSAQ-40). Instead, the neurological function measured with ALSFRS-S remained stable. Although the nature of this study design prevents any causal assumption, the positive results should lead to future randomized controlled trials to assess the effectiveness of OMT as an adjunctive therapeutic proposal to improve the health of ALS patients.
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  • 文章类型: Journal Article
    渗透性脱髓鞘综合征(ODS)是酗酒者脱髓鞘的主要原因之一,营养不良导致脑桥症状的各种临床表现,神经行为症状运动障碍以及言语和语言和吞咽困难。这项研究是为了使用MASA(吞咽能力的Mann评估)来反思ODS患者吞咽治疗的预后。一名36岁的男性,有经常饮酒和高血压的病史,在我们的医疗中心报告患有低钾血症和言语,语言和吞咽困难。脑部磁共振成像显示双侧基底神经节中的双侧对称T2和T2FLAIR(液体衰减倒置恢复)高强度病变,涉及尾状核,质质区和双侧丘脑,沿中脑有相似的病变。扩散研究中没有急性限制区域。这些发现提示了渗透性脱髓鞘综合征(ODS)。当使用N-DAT访问时,WAB和MASA;患者被诊断患有痉挛性构音障碍,经皮质运动性失语症和中度吞咽困难。使用言语和吞咽疗法进行干预,并以MASA评分进行内省时,在5天内观察到改善,统计学上97%的方差推断了MASA评分的进展趋势.这项研究得出的结论是,MASA可以成为内省ODS吞咽困难预后的有效工具,早期干预治疗吞咽困难显示出积极的结果。
    Osmotic Demyelination Syndrome (ODS) is one of the primary cause of demyelination in alcoholics and malnourished resulting in various kind of clinical manifestations in pontine symptoms, neuro-behavioural symptoms movement disorders as well as speech and language and swallowing difficulties. The study was done to introspect the prognosis of swallowing therapy in a patient with ODS using MASA (Mann Assessment of Swallowing Ability). A 36 years old male with a history of regular alcohol intake and hypertensiom reported in our healthcare centre with hypoaklemia and speech, language and swallowing difficulty. Magnetic resonance imaging of the brain showed bilateral symmetrical T2 and T2 FLAIR (fluid attenuated inversion recovery) hyperintensity lesion in the bilateral basal ganglia involving the caudate nuclei, putaminal region and bilateral thalami with similar lesion along the mid brain. There were no areas of acute restriction in diffusion study. The findings suggested of Osmotic Demyelination Syndrome (ODS).When accessed with N-DAT, WAB and MASA; patient was diagnosed with Spastic Dysarthria, Transcortical Motor Aphasia and Moderate Dysphagia. Intervention was provided using speech and swallowing therapy and when introspected with MASA scores, improvement was seen within 5 days and statistically 97% of variance was seen inferring the progressing trend in the MASA scores. This study concludes that MASA can be an effective tool in introspecting the prognosis of Dysphagia in ODS and early intervention in the management of dysphasia shows positive results.
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  • 文章类型: Journal Article
    嗜酸细胞性食管炎是一种公认的免疫介导的食道疾病,具有独特的临床和组织病理学特征,显示全球发病率增加。治疗选择包括饮食措施或药理学方法,包括质子泵抑制剂和外用皮质类固醇。目前单克隆抗体的使用情况正在综合评估中,大量正在进行的临床试验旨在确定其临床疗效。本病例报告显示一例难治性嗜酸细胞性食管炎,对常规治疗无反应,在开始贝那利珠单抗治疗后实现临床和组织病理学缓解.同时,我们的病例强调了在单克隆抗体领域继续研究的必要性,以便将其用作针对嗜酸性粒细胞性食管炎的未来治疗方法.
    Eosinophilic Esophagitis is a widely-recognized immune-mediated esophagus disease with distinct clinical and histopathological features, exhibiting an increased global incidence. Therapeutic options encompass either dietary measures or pharmacological approaches, including proton pump inhibitors and topical corticosteroids. The use of monoclonal antibodies is currently under comprehensive evaluation, with a plethora of ongoing clinical trials designed to determine their clinical efficacy. The present case report demonstrates an exceptional case of refractory Eosinophilic Esophagitis, unresponsive to conventional treatment, achieving both clinical and histopathological remission subsequent to initiation of benralizumab treatment. Concurrently, our case underscores the necessity for continued research in the field of monoclonal antibodies for their use as a future treatment approach against Eosinophilic Esophagitis.
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  • 文章类型: Case Reports
    吞咽困难是一种常见症状,具有各种潜在病因,使其管理具有挑战性,即使是经验丰富的医生。颈椎骨赘的存在通常会阻碍吞咽,使喉部移位,导致喉咙痛。我们描述了一例85岁的男性,他有两年的进行性吞咽困难病史,在过去的两个月里,尤其是固体食物和液体,提示耳鼻喉科评估。尽管之前有调查,包括正常胃镜检查和经验性疼痛管理,进一步评估显示下咽部肿块膨出,提示宫颈骨赘.保守管理,包括言语和吞咽疗法,饮食调整,和药物干预,在没有手术干预的情况下,症状明显改善。此病例证明了保守治疗措施治疗宫颈骨赘所致吞咽困难的有效性。强调多学科方法对优化患者护理的重要性。
    Dysphagia is a common symptom with various underlying etiologies, making its management challenging even for experienced physicians. The presence of osteophytes in the cervical spine may often impede swallowing, displace the larynx, and cause a sore throat. We describe a case of an 85-year-old male who presented with a two-year history of progressive dysphagia, exacerbated over the last two months, especially with solid foods and liquids, prompting an ENT evaluation. Despite prior investigations, including normal gastroscopy and empirical pain management, further assessment revealed bulging masses in the hypopharynx indicative of cervical osteophytes. Conservative management, including speech and swallow therapy, dietary modifications, and pharmacological interventions, resulted in significant symptom improvement without surgical intervention. This case demonstrates the effectiveness of conservative treatment measures in treating dysphagia caused by cervical osteophytes, emphasizing the significance of a multidisciplinary approach for optimal patient care.
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  • 文章类型: Journal Article
    一名五岁男性,患有痉挛性四肢瘫痪脑瘫和表达性沟通障碍,因为家庭希望饮食自由化。由于在床边吞咽评估中发现的缺陷,饮食由固体和液体组成;由于严重的手术焦虑,尚未获得进一步的吞咽困难评估。采取了涉及丁螺环酮预处理的综合方法,脱敏,分心,和积极的强化。荧光镜吞咽研究成功完成,患者的饮食被升级为包括中等稠度的液体。
    特殊人群的程序性焦虑管理没有得到很好的研究。缺乏关于这些问题的明确建议增加了管理这些患者的难度。此案例突出了一种使用广泛可用的药理学和环境技术来解决个人需求的成功方法。此外,这种情况下,有必要确定潜在的原因,程序焦虑,并涉及一个跨学科的团队。
    应尝试确定驱动程序焦虑的因素。在与病人和家属讨论之后,相关信息应传达给工作人员,并邀请他们提出想法。虽然并非所有医院都有同等的资源,与不熟悉有关的担忧,潜在的焦虑,控制源可以通过有限的资源利用来解决,正如在这种情况下所证明的那样。
    UNASSIGNED: A five-year-old male with spastic quadriplegia cerebral palsy and an expressive communication disorder presented because the family desired liberalization of diet. The diet consisted of pureed solids and no liquids due to deficits identified on bedside swallow evaluation; further dysphagia assessment had not been obtained due to significant procedural anxiety. Comprehensive approaches were taken involving premedication with buspirone, desensitization, distraction, and positive reinforcement. The fluoroscopic swallow study was successfully completed, and the patient\'s diet was upgraded to include moderately thickened liquids.
    UNASSIGNED: Procedural anxiety management in special populations is not well-researched. The lack of definitive recommendations regarding these issues increases the difficulty of managing these patients. This case highlights one successful approach to addressing individual needs using widely-available pharmacologic and environmental techniques. Additionally, this case reinforces the need to identify underlying causes for procedural anxiety and involve an interdisciplinary team.
    UNASSIGNED: Attempts should be made to identify factors driving procedural anxiety. After discussing with the patient and family, relevant information should be relayed to staff with an open-ended invitation to propose ideas. While not all hospitals have equivalent resources, concerns related to unfamiliarity, underlying anxiety, and locus of control can be addressed with limited resource utilization, as demonstrated in this case.
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  • 文章类型: Journal Article
    引言针对体重减轻的营养干预对于治疗肌萎缩侧索硬化症(ALS)是有用的。然而,营养干预后身体成分的变化仍不清楚.我们在此介绍了患有ALS的患者,其由于营养治疗和体育锻炼而经历了增加的体重和肌肉质量。病例介绍一名86岁的男子出现吞咽困难和构音障碍。患者被诊断为球型ALS。随着减肥的进展,进行了胃造口术。发病21个月后,由于保险杠溃疡引起的消化道出血导致进一步的体重减轻(从40.2kg降至36.8kg)。患者经历了行走困难和口服食物。尽管每天的总能量消耗(TDEE)估计为1,122千卡/天,超过计算的TDEE每天摄入1,500千卡。除了通常的康复外,患者还继续进行日常自愿锻炼。5个月后,他的体重从36.8公斤增加到40.4公斤。肌肉质量从25.1公斤增加到30.1公斤,使用多频生物电阻抗装置测量。肌肉力量从8.5/10.0kg提高到15.0/18.0kg,舌压从15.2kPa提高到20.4kPa。患者的身体和吞咽功能也得到改善。结论在ALS患者中,适当的营养治疗和体育锻炼可以改善因急性疾病引起的体重和肌肉质量下降。
    Introduction Nutritional interventions targeting weight loss are useful for the treatment of amyotrophic lateral sclerosis (ALS). However, the changes in body composition after nutritional intervention remain unclear. We herein present a patient with ALS who experienced an increased weight and muscle mass owing to nutritional therapy and physical exercise. Case Presentation An 86-year-old man presented with dysphagia and dysarthria. The patient was diagnosed with bulbar-type ALS. As weight loss progressed, a gastrostomy was performed. After 21 months of disease onset, gastrointestinal bleeding due to a bumper ulcer led to further weight loss (from 40.2 kg to 36.8 kg). The patient experienced difficulty walking and ingesting food orally. Although the total daily energy expenditure (TDEE) was estimated to be 1,122 kcal/day, an intake of 1,500 kcal/day beyond the calculated TDEE was administered. The patient continued to perform daily voluntary exercises in addition to his usual rehabilitation. After 5 months, his weight increased from 36.8 kg to 40.4 kg. Muscle mass increased from 25.1 kg to 30.1 kg, as measured using a multifrequency bioelectrical impedance device. Muscle strength improved from 8.5/10.0 kg to 15.0/18.0 kg in grip strength and from 15.2 kPa to 20.4 kPa in tongue pressure. The patient\'s physical and swallowing functions also improved. Conclusion In patients with ALS, a decreased body weight and muscle mass due to acute disease may be improved by appropriate nutritional therapy and physical exercise.
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  • 文章类型: Case Reports
    存在多种外科治疗方法来治疗内收肌痉挛性发声障碍(ADSD),其中选择性内收肌喉返神经神经支配和神经支配(SLAD-R)是最受欢迎的方法之一。我们介绍了SLAD-R的双侧声带麻痹(BVFP)病例,导致需要全喉切除术。我们建议BVFP比报道的更常见,我们都必须确保对手术患者进行最佳的长期随访。喉镜,2024.
    A variety of surgical treatment options exist for adductor spasmodic dysphonia (ADSD) with selective adductor recurrent laryngeal nerve denervation and reinnervation (SLAD-R) being one of the more popular. We present a case of bilateral vocal fold paralysis (BVFP) for SLAD-R resulting in the need for total laryngectomy. We suggest BVFP is more common than reported and that we all must insure optimal long term follow up of our surgical patients. Laryngoscope, 2024.
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