姜黄素,作为抗肿瘤剂,由于其代谢物在癌组织中缺乏有效水平,因此未广泛用于癌症治疗。解决载体的障碍和将药物递送到治疗作用的特定部位,同时减少副作用是优先事项。叶酸受体在恶性细胞中表达高,在正常细胞中表达低。叶酸作为靶向配体可以选择性地靶向癌细胞。因此,这篇叙述性综述旨在概述研究不同类型叶酸修饰的姜黄素作为载体和传递剂的研究及其增强治疗药物疗效的结构特性.使用PubMed进行文献检索,Scopus,WebofScience,和谷歌学者数据库。确定了针对该主题的38项临床前研究。目前的研究结果表明,叶酸修饰的纳米颗粒含有姜黄素作为一种有前途的治疗方法可以有效地改善不同类型的癌症。体外研究显示了更高的细胞摄取和细胞毒性效应,更高的细胞抑制,和抗增殖与较低剂量的姜黄素。体内研究表明,在施用叶酸修饰的含有姜黄素的纳米颗粒后,肿瘤抑制更多,肿瘤体积更小,没有毒性。未来的临床试验需要证实叶酸修饰的姜黄素作为癌症治疗新的药物递送平台的有益效果。
Curcumin, as an anti-tumor agent, is not widely used in cancer treatment due to the lack of effective levels of its metabolites in cancerous tissue. Addressing the barriers to the carrier and delivery of drugs to the specific sites of therapeutic action while reducing side effects is a priority. Folate receptor expression is high in malignant and low in normal cells. Folate as a targeted ligand could selectively target cancer cells. Thus, this narrative
review aimed to provide an overview of the studies that have investigated the different types of folate-modified curcumin as a carrier and deliverer and their structural properties that enhance therapeutic drug efficacy. A literature search was performed using PubMed, Scopus, Web of Science, and Google Scholar databases. Thirty-eight preclinical studies addressing this topic were identified. The findings of the current
review have shown that folate-modified nanoparticles containing curcumin as a promising therapeutic approach can be effective in improving different types of cancers. In vitro studies have shown a higher cellular uptake and cytotoxicity effect, higher cell inhibition, and anti-proliferation with a lower dosage of curcumin. In vivo studies have shown more tumor suppression and smaller tumor volume without toxicity after the administration of folate-modified nanoparticles containing curcumin. Future clinical trials are needed to confirm the beneficial effect of folate-modified curcumin as a new drug delivery platform for cancer treatment.