背景：对乙酰氨基酚（对乙酰氨基酚）是一种非常常见的OTC药物，在作为疼痛出售的200多种OTC产品中发现，咳嗽和感冒药。扑热息痛通常用作解热药以减轻发烧，并作为某些患者禁用的非甾体类抗炎药（NSAID）的替代品，以缓解轻度-中度疼痛。
目的：这篇综述的重点是SJS，十,SJS/TEN重叠，AGEP,和使用扑热息痛或含扑热息痛产品相关的DRESS综合征。
方法：要查找与扑热息痛相关的SJS相关的已发表文章，十,AGEP,和连衣裙,我们搜索了在线数据库Medline/Pubmed/PMC，谷歌学者，科学直接，Ebsco,Scopus,WebofScience,Embase,和参考列表使用关键词，如史蒂文斯-约翰逊综合症，对乙酰氨基酚,扑热息痛,中毒性表皮坏死松解症，急性泛发性发疹性脓疱病，药物反应伴嗜酸性粒细胞增多和全身症状。
结果：扑热息痛相关的SJS，十,SJS/TEN重叠，AGEP,和DRESS综合征已被许多出版物确定。
结论：在评估药物引起的过敏性皮肤反应时，医疗保健专业人员,包括开处方者,药剂师,和其他人,应该意识到这种罕见的风险。表现出扑热息痛相关超敏反应的体征和症状的患者应由药剂师转诊给医生进行进一步治疗。在服用扑热息痛时出现皮疹或其他过敏反应的第一个迹象，病人应该被告知停止服用，并立即去看医生。
Paracetamol (Acetaminophen) is a very common OTC drug that is found in more than 200 OTC products sold as pain, cough and cold remedies. Paracetamol is commonly used as an antipyretic to reduce fever and as an alternative to Non-steroidal anti-inflammatory drugs (NSAIDs) that are contraindicated in certain patients to relieve mild-moderate pain.
This
review article focuses on SJS, TEN, SJS/TEN overlap, AGEP, and DRESS syndromes associated with the use of paracetamol or paracetamol-containing products.
To find published articles relevant to paracetamol-associated SJS, TEN, AGEP, and DRESS, we searched the online databases Medline/Pubmed/PMC, Google Scholar, Science Direct, Ebsco, Scopus, Web of Science, Embase, and reference lists using keywords like Stevens-Johnson Syndrome, Acetaminophen, Paracetamol, Toxic epidermal necrolysis, Acute generalized exanthematous pustulosis, Drug reaction with eosinophilia and systemic symptoms.
The paracetamol-associated SJS, TEN, SJS/TEN overlap, AGEP, and DRESS syndromes have been identified by a number of publications.
When evaluating drug-induced hypersensitivity skin reactions, healthcare professionals, including prescribers, pharmacists, and others, should be aware of this rare risk. Patients who exhibit signs and symptoms of paracetamol-associated hypersensitivity should be referred to physicians by pharmacists for further treatment. At the first sign of a skin rash or other hypersensitivity reaction while taking paracetamol, patients should be told to stop taking it and see a doctor right away.
