■COVID-19幸存者的长期预后仍然知之甚少。事实证明,肺是COVID-19幸存者的主要受损器官,最明显的是肺弥散功能受损。因此,我们对恢复期COVID-19患者一氧化碳弥散能力(DLCO)受损的潜在危险因素进行了荟萃分析.
■我们对PubMed进行了系统搜索,WebofScience,Embase,和Ovid数据库从开始到2022年1月7日的相关研究,仅限于涉及人类受试者的论文。对方法学质量的研究进行了综述。使用固定效应和随机效应模型来汇集结果。使用I2评估异质性。使用Egger检验评估发表偏倚。PROSPERO注册:CRD42021265377。
■共确定了18篇合格文章,并将其纳入系统评价,12项研究纳入荟萃分析.我们的结果显示,女性(OR:4.011;95%CI:2.928-5.495),改变的胸部计算机断层扫描(CT)(OR:3.002;95%CI:1.319-6.835),年龄(OR:1.018;95%CI:1.007-1.030),较高的D-二聚体水平(OR:1.012;95%CI:1.001-1.023)和尿素氮(OR:1.004;95%CI:1.002-1.007)被确定为DLCO受损的危险因素.
■肺弥散能力是COVID-19康复患者中最常见的肺功能受损。几个危险因素,比如女性,胸部CT改变,年龄较大,较高的D-二聚体水平和尿素氮与DLCO的损害相关。提高对可能的可改变的危险因素的认识和实施干预措施对于肺康复可能是有价值的。
■这项工作得到了广州实验室应急重点项目(EKPG21-29,EKPG21-31)的资助,广州医科大学国家杰出青年科学基金孵化计划(GMU2020-207).
UNASSIGNED: The long-term prognosis of COVID-19 survivors remains poorly understood. It is evidenced that the lung is the main damaged organ in COVID-19 survivors, most notably in impairment of pulmonary diffusion function. Hence, we conducted a meta-analysis of the potential risk factors for impaired diffusing capacity for carbon monoxide (
DLCO) in convalescent COVID-19 patients.
UNASSIGNED: We performed a systematic search of PubMed, Web of Science, Embase, and Ovid databases for relevant studies from inception until January 7, 2022, limited to papers involving human subjects. Studies were reviewed for methodological quality. Fix-effects and random-effects models were used to pool results. Heterogeneity was assessed using I2. The publication bias was assessed using the Egger\'s test. PROSPERO registration: CRD42021265377.
UNASSIGNED: A total of eighteen qualified articles were identified and included in the systematic
review, and twelve studies were included in the meta-analysis. Our results showed that female (OR: 4.011; 95% CI: 2.928-5.495), altered chest computerized tomography (CT) (OR: 3.002; 95% CI: 1.319-6.835), age (OR: 1.018; 95% CI: 1.007-1.030), higher D-dimer levels (OR: 1.012; 95% CI: 1.001-1.023) and urea nitrogen (OR: 1.004;95% CI: 1.002-1.007) were identified as risk factors for impaired
DLCO.
UNASSIGNED: Pulmonary diffusion capacity was the most common impaired lung function in recovered patients with COVID-19. Several risk factors, such as female, altered chest CT, older age, higher D-dimer levels and urea nitrogen are associated with impairment of
DLCO. Raising awareness and implementing interventions for possible modifiable risk factors may be valuable for pulmonary rehabilitation.
UNASSIGNED: This work was financially supported by Emergency Key Program of Guangzhou Laboratory (EKPG21-29, EKPG21-31), Incubation Program of National Science Foundation for Distinguished Young Scholars by Guangzhou Medical University (GMU2020-207).