背景:诸如全身性类维生素A和抗生素等药物疗法在治疗头皮解剖性蜂窝织炎(DCS)中显示出疗效,但是难治性病例很常见。5-氨基酮戊酸光动力疗法(ALA-PDT)近年来已成功用于耐药病例。
方法:共有12名接受ALA-PDT治疗以及正式失败的药物治疗的患者通过电话进行了关于症状改善的访谈。满意,和副作用。
结果:总体而言,58.3%的患者至少有一种症状改善超过50%,16.7%的患者症状改善不大。疼痛改善超过50%的患者比例,瘙痒,肿胀和化脓占36.4%,66.7%,分别为33.3%和58.3%。41.7%的患者对ALA-PDT满意或非常满意。副作用主要是疼痛和结痂,大多轻微,恢复迅速。
结论:ALA-PDT作为全身药物治疗的辅助手段,在减轻DCS症状方面是安全且部分有效的。
BACKGROUND: Medicinal therapies such as systemic retinoids and antibiotics have shown efficacy in the treatment of dissecting cellulitis of the scalp (DCS), but refractory cases are common. 5-Aminolevulinic acid photodynamic therapy (ALA-PDT) has been successfully used in medicine-resistant cases in recent years.
METHODS: A total of 12 patients who received ALA-PDT in addition to formally failed medicinal therapies were interviewed by telephone regarding improvement of symptoms, satisfaction, and side effects.
RESULTS: Overall, 58.3 % patients achieved greater than 50 % improvement of at least one symptom, and 16.7 % had little improvement for any symptom. The proportion of patients who had greater than 50 % improvement for pain, pruritus, swelling and suppuration were 36.4 %, 66.7 %, 33.3 % and 58.3 % respectively. 41.7 % patients were either satisfied or very satisfied with the ALA-PDT. The side effects were mainly pain and crusting that were mostly mild and recovered quickly.
CONCLUSIONS: ALA-PDT was safe and partially effective in reducing DCS symptoms as an adjunct to systemic medicinal therapies.