背景:测试甲基氯异噻唑啉酮/甲基异噻唑啉酮(MCI/MI)和甲基异噻唑啉酮(MI)以检测对这些异噻唑啉酮的接触过敏。
目的:为了研究MCI和MI在0.015%和0.2%的混合物中的水性斑贴试验制剂,分别,在0.02%aq中检测到比常用的MCI/MI制剂更多的接触过敏。和MI在0.2%aq。
方法:对瑞典五个皮肤科的1555例皮炎患者进行了MCI/MI0.215%aq连续检测。,MCI/MI0.02%aq。,和MI0.2%aq。
结果:接触过敏对MCI/MI的比例为0.215%。,MCI/MI0.02%aq。,和MI0.2%aq。测试中心的差异在7.9%到25.9%之间,3.2%和10.3%,5.8%和12.3%,分别。MCI/MI0.215%aq。检测到的斑贴试验阳性个体明显多于MCI/MI0.02%aq。(P<.001)和MI0.2%aq。(P<.001),以及MCI/MI和MI之一(P<.001)。在仅对MCI/MI有反应的患者中,0.215%aq。,57.7%的人被记录为患有通过暴露于MCI/MI或MI而被解释或加重的皮炎。
结论:结果有利于替代MCI/MI0.02%水溶液制剂。和MI0.2%aq。与MCI/MI0.215%aq。作为瑞典基线系列中的筛选物质,已于2020年实施。
BACKGROUND: Methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) and methylisothiazolinone (MI) are tested to detect contact allergy to these isothiazolinones.
OBJECTIVE: To
study if an aqueous patch test preparation with MCI and MI in a mix of 0.015% and 0.2%, respectively, detects more contact allergies than the commonly used preparations of MCI/MI in 0.02% aq. and MI in 0.2% aq.
METHODS: A total of 1555 patients with dermatitis in five Swedish dermatology departments were tested consecutively with MCI/MI 0.215% aq., MCI/MI 0.02% aq., and MI 0.2% aq.
RESULTS: The share of contact allergy to MCI/MI 0.215% aq., MCI/MI 0.02% aq., and MI 0.2% aq. varied in the test centers between 7.9% and 25.9%, 3.2% and 10.3%, and 5.8% and 12.3%, respectively. MCI/MI 0.215% aq. detected significantly more patch-test positive individuals than both MCI/MI 0.02% aq. (P < .001) and MI 0.2% aq. (P < .001), as well as either one of MCI/MI and MI (P < .001). In the patients only reacting to MCI/MI 0.215% aq., 57.7% were recorded as having a dermatitis that was explained or aggravated by exposure to either MCI/MI or MI.
CONCLUSIONS: The results speak in favor of replacing the preparations MCI/MI 0.02% aq. and MI 0.2% aq. with MCI/MI 0.215% aq. as the screening substance in the Swedish baseline series, which has been implemented in 2020.