近年来已经观察到可降解材料在医学中的使用显著增加,这是由于它们对患者的影响最小和广泛的适用性。生物可降解聚合物聚二恶烷酮(PDO)提供了在医学领域中可以代表上述医疗材料的这种聚合物的使用的良好实例。由于其高水平的生物相容性和有趣的机械性能。PDO用于生产可吸收医疗设备,如缝合线和支架,也适用于某些矫形植入物的制造。聚二恶烷酮由于其热塑性性质,可以使用注塑方法进行加工;该方法可以精确且易于控制地生产医疗材料,而无需有毒添加剂。基于这种加工方法,许多小型商业聚合物植入物最近已被引入市场。重要的是要注意,到目前为止,科学或公众都没有关于PDO成型的相关信息,并且尚未发表描述PDO注射成型潜力的研究。因此,我们介绍了我们对基本技术和材料参数的研究,这些参数允许使用实验室微注射成型方法处理PDO。除了确定工艺的基本参数外,该研究还着重于基于加工过程中的热条件对样品的结构和机械性能的研究。通过微注塑成型方法成功确定了PDO加工的技术框架,该方法可以生产具有所需均匀性的样品。形状稳定性和表面质量在实验室规模。研究表明,PDO是一种具有主要结晶相的聚合物,并且它对模具中的退火温度分布敏感,有可能影响最终的晶体结构,断口形貌和力学性能。
Recent years have observed a significant increase in the use of degradable materials in medicine due to their minimal impact on the patient and broad range of applicability. The biodegradable polymer Polydioxanone (PDO) provides a good example of the use of such one polymer that can represent the aforementioned medical materials in the field of medicine, due to its high level of biocompatibility and interesting mechanical properties. PDO is used to produce absorbable medical devices such as sutures and stents, and is also suitable for the fabrication of certain orthopedic implants. Polydioxanone can be processed using the injection molding method due to its thermoplastic nature; this method allows for the precise and easily-controllable production of medical materials without the need for toxic additives. A number of small commercial polymer implants have recently been introduced onto the market based on this processing method. It is important to note that, to date, no relevant information on the molding of PDO is available either for the scientific or the general public, and no
study has been published that describes the potential of the injection molding of PDO. Hence, we present our research on the basic technological and material parameters that allow for the processing of PDO using the laboratory microinjection molding method. In addition to determining the basic parameters of the process, the research also focused on the
study of the structural and mechanical properties of samples based on the thermal conditions during processing. A technological frame work was successfully determined for the processing of PDO via the microinjection molding approach that allows for the production of samples with the required homogeneity, shape stability and surface quality in a laboratory scale. The research revealed that PDO is a polymer with a major share of crystalline phases, and that it is sensitive to the annealing temperature profile in the mold, which has the potential to impact the final crystalline structure, the fracture morphology and the mechanical properties.