deglutition disorders

吞咽障碍
  • 文章类型: Journal Article
    颈椎前路手术后的吞咽困难在手术后1年后的发生率为5%至15%,通常归因于机械因素,如咽部增厚和会厌内翻。尽管神经系统检查和肌电图正常,在这些患者中,与拉伸相关的神经变形也仍然存在可能性,并可能导致异常性疼痛,导致吞咽困难和吞咽困难。颈椎前路椎间盘切除术和融合术后吞咽困难的当前治疗选择仅限于局部术中类固醇注射和气管牵引锻炼。在我们的病人身上,舌咽神经阻滞有效地用于控制舌咽异常痛,从而减少吞咽困难和吞咽困难,最终增强口服耐受性。
    Dysphagia after anterior cervical spine surgery has a 5% to 15% incidence beyond 1-year postsurgery, often attributed to mechanical factors such as pharyngeal thickening and epiglottis inversion. Despite normal neurological examination and electromyography, nerve distortion related to stretching also remains a possibility in these patients and may cause allodynia resulting in odynophagia and dysphagia. Current treatment options for dysphagia after anterior cervical discectomy and fusion are limited to local intraoperative steroid injections and tracheal traction exercises. In our patient, a glossopharyngeal nerve block was effectively used to manage the glossopharyngeal allodynia, thereby reducing the odynophagia and dysphagia, ultimately enhancing oral tolerance.
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  • 文章类型: Journal Article
    目的:在糖尿病(DM)患者中,与胃肠外营养(PN)相比,肠内营养(EN)与更少的高血糖和更低的胰岛素需求有关。这项研究的主要目的是评估EN治疗的DM患者的血糖控制(GC)变化。次要目标包括通过监测潜在的胃肠道副作用来评估专门配方对各种临床参数和营养配方的耐受性的影响。
    方法:我们报告了一系列关于糖尿病特异性配方(DSF)对GC的影响的病例,血脂谱(LP),接受EN支持的DM队列中的肾功能和肝功能。
    结果:22名患有完全吞咽困难的DM受试者(13名男性,观察到9名妇女)接受连续EN。在EN中使用DSF与所有研究患者的血糖指数改善相关。导致平均胰岛素需求减少。在研究期间没有报告住院治疗。
    结论:研究表明,在多维家庭护理管理环境中使用DSF可以改善血糖控制,减少血糖变异性和胰岛素需求,并对DM队列的血脂状况产生积极影响。观察到的临床结果支持代谢改善。
    OBJECTIVE: In patients with Diabetes Mellitus (DM), Enteral Nutrition (EN) is associated with less hyperglycemia and lower insulin requirements compared to Parenteral Nutrition (PN). The primary aim of this study was to assess changes in glycemic control (GC) in DM patients on EN therapy. The secondary objectives included evaluating the impact of the specialized formula on various clinical parameters and the tolerability of the nutritional formula by monitoring potential gastrointestinal side effects.
    METHODS: We report a case series on the effects of a Diabetes-Specific Formula (DSF) on GC, lipid profile (LP), and renal and hepatic function in a DM cohort receiving EN support.
    RESULTS: Twenty-two DM subjects with total dysphagia (thirteen men, nine women) on continuous EN were observed. The use of a DSF in EN was associated with an improvement in glycemic indices across all patients studied, leading to a reduction in average insulin demand. No hospitalizations were reported during the study period.
    CONCLUSIONS: The study demonstrated that the use of DSFs in a multi-dimensional home care management setting can improve glycemic control, reduce glycemic variability and insulin need, and positively impact the lipid profile of the DM cohort. The metabolic improvements were supported by the clinical outcomes observed.
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  • 文章类型: Case Reports
    原发性喉部淋巴瘤很罕见,占所有喉癌的不到1%。治疗取决于疾病的阶段和严重程度。我们在这里报道了一个64岁女性的特殊案例,非吸烟者,患有吞咽困难的固体和异物感。喉镜检查和活检显示左会厌褶皱多倍体肿瘤。诊断为弥漫性大B细胞淋巴瘤。患者接受化疗后再接受放疗,在2年的随访中显着改善,没有局部复发。由于这种疾病的罕见性和各种症状,这种癌症的最佳管理策略是有争议的,需要特定的诊断和治疗方法。
    Primary laryngeal lymphoma is rare, accounting for less than 1% of all laryngeal cancers. Treatment depends on the stage and severity of the disease. We here report the exceptional case of a 64-year-old woman, non-smoker, suffering from dysphagia for solids and a foreign body sensation. Laryngoscopy and biopsies revealed polyploid tumor of the left epiglottic fold. The diagnosis of diffuse large B-cell lymphoma was made. The patient underwent chemotherapy followed by radiotherapy, with significant improvement at 2-year follow-up, with no local recurrence. Due to the rarity of this disease and the variety of symptoms, the optimal management strategy for this type of cancer is controversial, requiring a specific diagnostic and therapeutic approach.
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  • 文章类型: Case Reports
    背景:颈前路椎间盘切除融合术(ACDF)后吞咽困难是一种常见的术后并发症。然而,关于术后吞咽困难康复策略的信息有限.在这里,我们报告了一种治疗ACDF后吞咽困难的代偿策略.
    方法:一名65岁的亚洲男性,表现为左臂疼痛和虚弱超过1个月。颈椎的磁共振成像显示椎间盘退行性病变和C3至C7水平的椎管狭窄。患者接受C3至C5水平的ACDF和通过右侧入路在C5至C7水平的人工椎间盘置换。手术后,患者抱怨吞咽困难。视频透视吞咽研究(VFSS)在咽部阶段检测到吞咽功能障碍,在前后视图中显示不对称的咽部残留物。
    方法:患者在ACDF后被诊断为吞咽困难。
    方法:基于VFSS的发现,患者接受了吞咽康复治疗和代偿技术,例如头部旋转到弱右侧和头部倾斜到坚固的左侧。
    结果:经过2个月的补偿技术康复,食物平稳地向健壮的一面移动,吞咽困难的主观症状得到改善。
    结论:因此,必须评估ACDF手术后的吞咽功能;如果检测到单侧吞咽困难,补偿技术可能被证明是有益的。这个案例研究表明,根据VFSS的客观发现,可以建立有效的吞咽补偿策略,并将其应用于术后吞咽困难的患者。
    BACKGROUND: Dysphagia after anterior cervical discectomy and fusion (ACDF) is a common postoperative complication. However, information regarding rehabilitation strategies for postoperative dysphagia is limited. Herein, we report a compensatory strategy for treating dysphagia after ACDF.
    METHODS: A 65-year-old Asian male presented with left arm pain and weakness for more than 1 month. Magnetic resonance imaging of the cervical spine revealed degenerative disc lesions and spinal stenosis at the C3 to C7 levels. The patient underwent ACDF at the C3 to C5 levels and artificial disc replacement at the C5 to C7 levels by right side approach. After surgery, the patient complained of difficulty swallowing. A video fluoroscopic swallowing study (VFSS) detected swallowing dysfunction in the pharyngeal phase, revealing an asymmetric pharyngeal residue in the anterior-posterior view.
    METHODS: The patient was diagnosed with dysphagia after ACDF.
    METHODS: Based on the VFSS findings, the patient underwent swallowing rehabilitation therapy and compensatory techniques, such as head rotation to the weak right side and head tilting to the robust left side.
    RESULTS: After 2 months of rehabilitation with compensatory techniques, food moved smoothly towards the robust side, and the subjective symptoms of dysphagia improved.
    CONCLUSIONS: Consequently, swallowing function post-ACDF surgery must be assessed; if unilateral dysphagia is detected, compensatory techniques may prove beneficial. This case study showed that, based on the objective findings of the VFSS, an effective swallowing compensation strategy can be established and applied to patients with postoperative dysphagia.
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  • 文章类型: Case Reports
    背景:神经节神经瘤病是一种罕见的良性神经源性肿瘤,通常影响腹膜后和后纵隔的主要交感神经节部位。胃肠道的影响是罕见的,和食管的参与是例外的。据我们所知,文献中仅报道了4例成人食管神经节神经瘤病。在儿科年龄组中没有病例报告。
    方法:一名11岁男孩因食管神经节神经瘤病引起的严重食管狭窄而出现吞咽困难。
    结论:尽管它很少,本病例提示特发性食管狭窄患儿应考虑神经节神经瘤病。
    BACKGROUND: Ganglioneuromatosis is a rare type of benign neurogenic tumor that usually affects the sites of the major sympathetic ganglia in the retroperitoneum and the posterior mediastinum. Affection of the gastrointestinal tract is rare, and involvement of the esophagus is exceptional. To the best of our knowledge, only 4 cases of esophageal ganglioneuromatosis in adults were reported in the literature. No cases have been reported in the pediatric age group.
    METHODS: An 11-year-old boy presented with dysphagia due to severe esophageal stenosis caused by esophageal ganglioneuromatosis.
    CONCLUSIONS: Despite its rarity, the present case implies that ganglioneuromatosis should be considered in children with idiopathic esophageal stenosis.
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  • 文章类型: Case Reports
    背景:多发性骨髓瘤(MM)伴继发性淀粉样变性(AL)是一种罕见的克隆性浆细胞增殖疾病,导致多个器官和组织功能障碍。我们报告了一例吞咽困难是MM和继发性AL患者的首发症状。
    方法:患者是一名73岁的女性,住进了我们的医院,因为进行性吞咽困难4个月,肢体无力1个月。
    方法:骨髓涂片和病理诊断提示存在MM,二头肌肌病诊断提示AL。
    方法:VCD方案包括在第1、8、15和22天剂量为1.9mg的硼替佐米,在第1、8和15天剂量为0.4g的环磷酰胺,以及在第1、8、15和22天剂量为40mg的地塞米松。患者同时接受包括抗感染治疗在内的综合治疗,增强心脏功能,和营养支持。
    结果:血中M蛋白和尿蛋白均为阴性,表明骨髓浆细胞减少到2%。流式细胞术分析显示最小百分比为0.04%。因此,完全缓解.
    结论:MM的临床表现范围广泛,二次损伤的症状引起了严重的不安,而髓外表现的非典型症状对诊断该病提出了挑战。
    BACKGROUND: Multiple myeloma (MM) with secondary amyloidosis (AL) is a rare clonal plasma cell proliferation disease, which causes dysfunction of multiple organs and tissues. We report a case of dysphagia as the first symptom in a patient with MM and secondary AL.
    METHODS: The patient was a 73-year-old female, was admitted to our hospital, because of progressive dysphagia for 4 months and limb weakness for 1 month.
    METHODS: The bone marrow smear and pathology diagnosis revealed the presence of MM, while the biceps myopathy diagnosis indicated AL.
    METHODS: The VCD regimen consisted of bortezomib at a dosage of 1.9 mg on days 1, 8, 15, and 22, cyclophosphamide 0.4 g on days 1, 8, and 15, and dexamethasone at a dosage of 40 mg on days 1, 8, 15, and 22. The patient simultaneously received comprehensive treatment including anti-infective therapy, enhanced cardiac function, and nutritional support.
    RESULTS: The M protein in the blood and urine protein were negative, indicating a reduction in bone marrow plasma cells to 2%. Flow cytometric analysis revealed a minimal percentage 0.04%. As a result, complete remission was achieved.
    CONCLUSIONS: The clinical manifestations of MM exhibit a wide range, with the symptoms of secondary injury causing significant disturbing, while the atypical symptoms of extramedullary manifestations pose challenges in diagnosing the disease.
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  • 文章类型: Case Reports
    背景:肌无力危象(MC)是重症肌无力(MG)的一种危及生命的并发症,需要通风。实现非典型肌无力危象的安全及时诊断,孤立的表现是一个相当大的挑战,特别是在老年患者中,在罕见的情况下,重症肌无力可以出现孤立的构音障碍,给腔隙性中风的临床印象。
    方法:我们介绍了一个令人信服的病例,一个73岁的白种人女性突然出现孤立构音障碍。尽管初步治疗了推测的腔隙性中风,随后的评估导致她诊断为肌无力危机。入院后72小时内,患者出现吞咽困难和呼吸急促,需要补充氧气。该病例突出了从孤立性构音障碍的非典型表现及其过程到肌无力危机的处理的事件的顺序进展。
    结论:我们报道的病例集中于对肌无力的讨论,该肌无力模仿腔隙性中风,并最终在医疗危机的关键时刻被诊断出来。这个案例强调了一个必要的观念,即老年人的孤立性构音障碍需要警惕地监测可能的重症肌无力,考虑到仅伴有构音障碍的腔隙卒中的低发生率。
    BACKGROUND: Myasthenic crisis (MC) is a life-threatening complication of myasthenia gravis (MG), necessitating ventilation. Achieving a safe and timely diagnosis of myasthenic crisis with atypical, isolated presentation is a considerable challenge particularly in elderly patients, where myasthenia gravis can present with isolated dysarthria in rare instances, giving a clinical impression of lacunar stroke.
    METHODS: We present a compelling case of a 73-year-old Caucasian female presenting with abrupt onset of isolated dysarthria. Despite initial treatment for a presumed lacunar stroke, subsequent evaluations led to her diagnosis of a myasthenic crisis. Within 72 h of admission, the patient developed dysphagia and shortness of breath, requiring supplemental oxygen. The case highlights the sequential progression of events from the atypical presentation of isolated dysarthria and its course to the management of a myasthenic crisis.
    CONCLUSIONS: Our reported case focuses on the discussion of myasthenia that mimicked a lacunar stroke and was finally diagnosed at a critical time of medical crisis. This case highlights the imperative notion that isolated dysarthria in elderly individuals warrants vigilant monitoring for possible myasthenia gravis, given the low incidence of lacunar stroke presenting with only dysarthria.
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  • 文章类型: Case Reports
    肌萎缩侧索硬化症(ALS)是一种无法治愈的罕见神经退行性疾病,45%的病例表现出吞咽困难的症状;其临床症状是萎缩,弱点,和面部肌肉的肌束,舌头,和咽部。此外,吞咽困难是吸入性肺炎的主要原因。吞咽困难的传统治疗方法因患者的吞咽困难而异。初始阶段包括饮食一致性调整,进展为替代如鼻胃管或经皮内镜胃造瘘术(PEG)在晚期阶段。整骨疗法(OMT)是一种补充的“动手”方法,已在各种健康状况下作为附加疗法显示出积极的结果。这项研究是一个被诊断患有ALS并伴有吞咽困难的男性的病例报告,使用非常包括OMT的协议进行管理。患者在纵隔区域表现出躯体功能障碍,上颈部,和枕骨区域在解剖学上都与神经系统相关,尤其是舌咽反射.在康复方案结束时,用StrandScale和吞咽测试测量的吞咽问题减少了,患者报告用肌萎缩侧索硬化评估问卷(ALSAQ-40)评估的心理-身体健康状况改善.相反,用ALSFRS-S测量的神经功能保持稳定。尽管这项研究设计的性质阻止了任何因果假设,阳性结果应导致未来的随机对照试验,以评估OMT作为改善ALS患者健康的辅助治疗方案的有效性.
    Amyotrophic lateral sclerosis (ALS) is an incurable rare neurodegenerative condition, with 45% of cases showing the symptom of dysphagia; its clinical signs are atrophy, weakness, and fasciculations of the facial muscles, tongue, and pharynx. Furthermore, dysphagia is the main cause of aspiration pneumonia. The traditional treatment for dysphagia varies based on the patient\'s difficulty of swallowing. The initial phase consists of dietary consistency adjustments, progressing to alternatives like nasogastric tubes or percutaneous endoscopic gastrostomy (PEG) in advanced stages. Osteopathic manipulative treatment (OMT) is a complementary \'hands-on\' approach that has already shown positive results as an add-on therapy in various health conditions. This study is a case report of a man diagnosed with ALS with initial dysphagia, managed with a protocol that extraordinarily included OMT. The patient showed somatic dysfunctions in the mediastinal region, upper cervical region, and occipital area which are all anatomically related to the nervous system, especially the glossopharyngeal reflex. At the end of the rehabilitation protocol, there was a reduction in the swallowing problems measured with Strand Scale and swallowing tests, and the patient reported an improved psycho-physical well-being assessed with the Amyotrophic Lateral Sclerosis Assessment Questionnaire (ALSAQ-40). Instead, the neurological function measured with ALSFRS-S remained stable. Although the nature of this study design prevents any causal assumption, the positive results should lead to future randomized controlled trials to assess the effectiveness of OMT as an adjunctive therapeutic proposal to improve the health of ALS patients.
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  • 文章类型: Case Reports
    放线菌病是一种罕见的内源性感染,其特征是进展缓慢,连续传播,脓肿形成和引流窦。这里,我们介绍了一例Schaaliadontolytica引起纵隔脓肿的病例,该脓肿的敏锐度和位置都很独特。我们的病人出现了恶化的吞咽困难,胸部CT显示后纵隔有新肿块移位食管。食道图显示轻度运动障碍,但食道内没有肿块或溃疡.内镜超声检查食管胃十二指肠镜检查显示食管外在压迫。肿块的细针抽吸产生了脓性液体,这是培养的。分离出单菌落。最初,医疗受到青睐,但当她出现吞咽困难时,脓肿被排干了。她在引流后继续接受长期抗生素治疗,并在1年时脓肿完全消退。
    Actinomycosis is a rare endogenous infection characterised by indolent progression, contiguous spreading, abscess formation and draining sinuses. Here, we present a case of Schaalia odontolytica causing a mediastinal abscess that is unique in its acuity and location. Our patient presented with worsening dysphagia, and CT of her chest revealed a new mass in the posterior mediastinum displacing the oesophagus. Oesophagram revealed mild motility disorder, but no masses or ulcers within the oesophagus. Oesophagogastroduodenoscopy with endoscopic ultrasound revealed extrinsic compression of the oesophagus. Fine-needle aspiration of the mass yielded purulent fluid, which was cultured. A single colony of S. odontolytica was isolated. Initially, medical treatment was favoured, but as she developed worsening dysphagia, the abscess was drained. She continued on long-term antibiotic therapy after drainage and had complete resolution of the abscess at 1 year.
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  • 文章类型: Case Reports
    The article presents a case of pharyngeal dysphagia and obstructive sleep apnea syndrome caused by degenerative-dystrophic changes in the cervical spine with the formation of large cervical osteophytes at the C3-C6 level. Osteophytes caused deformation of the posterior wall of the hypopharynx and narrowing of its lumen by 20-25% from the level of the arytenoid cartilages to the upper parts of the epiglottis. CT scan also showed the intervertebral disc heights lost, as well as osteophytes at the posterolateral margins of the vertebral bodies (disc osteophyte complex). Osteosclerosis in combination with facet arthrosis caused spinal and foraminal stenosis.
    В статье представлен клинический случай глоточной дисфагии и синдрома обструктивного апноэ сна, обусловленных дегенеративно-дистрофическими изменениями в шейном отделе позвоночника с образованием объемных костных экзостозов на передней поверхности тел CIII—CVI. Остеофиты деформировали заднюю стенку гортанной части глотки и на 20—25% сужали ее просвет на протяжении от уровня черпаловидных хрящей до верхних отделов надгортанника. Кроме остеофитов при проведении компьютерной томографии выявлено снижение высоты межпозвоночных дисков, а также краевые остеофиты тел позвонков, в том числе в заднебоковых отделах по ходу протрузии дисков (диско-остеофитные комплексы). Остеосклероз в сочетании с артрозом дугоотростчатых суставов вызвал сужение позвоночного и межпозвоночных отверстий.
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