未经证实:阿尔茨海默病(AD)和血管性痴呆(VaD)是老年人中两种最常见的神经退行性痴呆类型,具有相似的认知衰退症状和重叠的神经心理学特征。区分VaD患者和AD患者的生物学标记将非常有用。我们的目的是研究血脑屏障(BBB)相关血源性因子可溶性低密度脂蛋白受体相关蛋白1(sLRP1)的表达。亲环蛋白A(CyPA),和基质金属蛋白酶9(MMP9)及其与AD和VaD患者认知功能的相关性。
未经证实:sLRP1,CyPA的血浆水平,分析了26例AD患者的MMP9,27名VaD患者,和27个正常对照(NC)。Spearman的等级相关分析用于探索生物标志物水平之间的关系,认知功能,和成像参考。采用受试者工作特征(ROC)曲线分析鉴别诊断AD和VaD。
未经评估:在这些BBB相关因素中,VaD组血浆CyPA含量明显高于AD组(p<0.05)。血浆sLRP1水平在VaD中呈现增加趋势,而在AD患者中维持略低的水平(p>0.05)。不同诊断组血浆MMP9呈以下趋势:VaD组>AD组>NC组,但差异无统计学意义(p>0.05)。此外,血浆SLRP1水平与MoCA评分呈正相关,AD组血浆CyPA水平与MTA评分显著相关(p<0.05)。VaD组血浆MMP9水平与MoCA评分呈负相关(p<0.05)。其他因素与不同认知评分之间无显著相关性(p>0.05)。ROC分析显示血浆CyPA[AUC=0.725,95%CI(0.586-0.865);p=0.0064]在诊断中具有良好的偏好。
未经证实:在区分AD和皮质下缺血性血管性痴呆(SIVD)诊断时,血浆CyPA水平是参考指标。与BBB相关的血液来源因素可能为神经退行性痴呆的鉴别诊断提供新的见解,并需要进一步研究。
UNASSIGNED: Alzheimer\'s disease (AD) and vascular dementia (VaD) are the two most common types of neurodegenerative dementia among the elderly with similar symptoms of cognitive decline and overlapping neuropsychological profiles. Biological markers to distinguish patients with VaD from AD would be very useful. We aimed to investigate the expression of blood-brain barrier (BBB)-related blood-borne factors of soluble low-density lipoprotein receptor-related protein 1 (sLRP1), cyclophilin A (CyPA), and matrix metalloproteinase 9 (MMP9) and its correlation with cognitive function between patients with AD and VaD.
UNASSIGNED: Plasma levels of sLRP1, CyPA, and MMP9 were analyzed in 26 patients with AD, 27 patients with VaD, and 27 normal controls (NCs). Spearman\'s rank correlation analysis was used to explore the relationships among biomarker levels, cognitive function, and imaging references. Receiver operating characteristic (ROC) curve analysis was used to discriminate the diagnosis of AD and VaD.
UNASSIGNED: Among these BBB-related factors, plasma CyPA levels in the VaD group were significantly higher than that in the AD group (p < 0.05). Plasma sLRP1 levels presented an increasing trend in VaD while maintaining slightly low levels in patients with AD (p > 0.05). Plasma MMP9 in different diagnostic groups displayed the following trend: VaD group > AD group > NC group, but the difference was not statistically significant (p > 0.05). Furthermore, plasma sLRP1 levels were positively related to MoCA scores, and plasma CyPA levels were significantly correlated with MTA scores (p < 0.05) in the AD group. Plasma MMP9 levels were negatively correlated with MoCA scores (p < 0.05) in the VaD groups. No significant correlation was detected between the other factors and different cognitive scores (p > 0.05). ROC analysis showed a good preference of plasma CyPA [AUC = 0.725, 95% CI (0.586-0.865); p = 0.0064] in diagnosis.
UNASSIGNED: The plasma CyPA level is a reference index when distinguishing between an AD and subcortical ischemic vascular dementia (SIVD) diagnosis. Blood-derived factors associated with the BBB may provide new insights into the differential diagnosis of neurodegenerative dementia and warrant further investigation.