非甾体抗炎药(NSAID)具有优异的抗炎和镇痛特性,被广泛用于治疗创伤后或手术后的肌肉骨骼疼痛。虽然有大量的文献关于NSAID对动物骨愈合的给药,没有对研究NSAID给药对骨折愈合影响的动物研究进行系统评价和荟萃分析。本研究的目的是进行系统评价和荟萃分析,以评估NSAIDs给药对骨折手术后不同动物模型的骨愈合生物力学和组织形态测量的影响。
我们对动物研究进行了系统评价和荟萃分析,以评估骨折后NSAID给药对愈合结果的影响。我们搜索了8个数据库,但不限于从2021年2月1日开始搜索关于在给予NSAID的动物模型中骨折愈合的文章。
在筛选的6732篇文章中,纳入47例,分析了3种常见的骨愈合结果:生物力学特性(最大断裂力,刚度,和从工作到失败),显微计算机断层扫描(μ-CT),和组织形态测量。这些研究的质量普遍较低,因为关键信息,特别是关于随机化,盲法,和分配隐藏,报道不佳。我们的结果表明,与其他动物相比,NSAID对骨折后愈合骨的某些生物力学特性的负面影响在小鼠中没有统计学意义。女性与男性相比,与年长的动物相比,更年轻。
研究结果表明,与对照组相比,使用NSAIDs降低了骨折手术后愈合骨的生物力学特性。此外,在不同的地点之间检测到对某些结果的不同影响,动物的性别,以及评估的时间。
协议于2017年在SYstematic实验动物实验审查中心(SYRCLE)发布并注册,https://www。Radboudumc.nl/getmedia/757ec408-7a9e-4635-8233-ae951effea54/非甾体抗炎药和骨愈合动物模型-系统回顾和荟萃分析。aspx.
Non-steroidal anti-inflammatory drugs (NSAID) have excellent anti-inflammatory and analgesic properties and are extensively used to treat post-traumatic or surgical musculoskeletal pain. Although an extensive literature exists on the administration of NSAID on animal bone healing, no systematic
review and meta-analysis of animal studies that investigate the effect of NSAID administration on bone fracture healing. Objective of this study is to conduct a systematic
review and meta-analysis to estimate the effect of NSAIDs administration on bone healing biomechanical and histomorphometric measurements in different animal models after bone fracture surgery.
We performed a systematic
review and meta-analysis of animal studies to estimate the effect of NSAID administration after bone fracture on healing outcomes. We searched eight databases without limiting the search to starting date up to 1 February 2021 for articles on fractured bone healing in animal models in which NSAID were administered.
Out of 6732 articles screened, 47 were included and 3 common bone healing outcomes were analysed: biomechanical properties (maximum force to break, stiffness, and work-to-failure), micro-computed tomography (μ-CT), and histomorphometric measurements. The studies were generally of low-quality scores because crucial information, especially concerning randomization, blinding, and allocation concealment, was poorly reported. Our results show that the negative effects of NSAID after bone fracture on certain biomechanical properties of the healing bones was not statistically significant in mice compared with other animals, in females compared with males, and in younger compared with older animals.
The findings demonstrated that NSAIDs administration decreased the biomechanical properties of healing bones after fracture surgery in comparison to the control group. Moreover, different effect on certain outcomes was detected among different sites, sex of the animals, and the time of assessment.
Protocol published and registered in SYstematic
Review Center for Laboratory animal Experimentation (SYRCLE) in 2017, https://www.radboudumc.nl/getmedia/757ec408-7a9e-4635-8233-ae951effea54/Non-Steroidal-Anti-inflammatory-Drugs-and-bone-healing-in-animal-Models-Systematic-
Review-and-Meta-Analysis.aspx.