■立方体是纳米结构的基于脂质的颗粒,在药物递送和纳米医学领域获得了极大的关注。这些独特的结构由通过脂质分子的自组装形成的三维立方晶格组成。用于构建立方体的脂质通常是非离子表面活性剂,如单油酸甘油酯,具有亲水和疏水区域,让它们形成稳定,水分散性纳米粒子。立方体的关键优点之一是它们能够包封和递送疏水性和亲水性药物。脂质双层的疏水区域为掺入亲脂性药物提供了理想的环境,而亲水区域可以包裹水溶性药物。这种多功能性使立方体适用于提供广泛的治疗剂,包括小分子,蛋白质,肽,和核酸。立方体的独特结构还提供了稳定性和受控释放的益处。脂质双层提供了保护性屏障,屏蔽封装的药物从降解和提高其稳定性。此外,立方晶格排列能够通过改变脂质组成和表面修饰来调节药物释放动力学。这允许开发持续或触发的药物释放系统,提高治疗效果,减少副作用。此外,立方体可以很容易地用靶向配体或表面修饰来修饰,以实现位点特异性药物递送,增强治疗选择性和减少脱靶效应。总之,立方体为治疗剂的输送提供了一个多功能和有前途的平台。在这份手稿中,我们将重点介绍其中的一些应用。
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UNASSIGNED: Cubosomes are nanostructured lipid-based particles that have gained significant attention in the field of drug delivery and nanomedicine. These unique structures consist of a three-dimensional cubic lattice formed by the self-assembly of lipid molecules. The lipids used to construct cubosomes are typically nonionic surfactants, such as monoolein, which possess both hydrophilic and hydrophobic regions, allowing them to form stable, water-dispersible nanoparticles. One of the key advantages of cubosomes is their ability to encapsulate and deliver hydrophobic as well as hydrophilic drugs. The hydrophobic regions of the lipid bilayers provide an ideal environment for incorporating lipophilic drugs, while the hydrophilic regions can encapsulate water-soluble drugs. This versatility makes cubosomes suitable for delivering a wide range of therapeutic agents, including small molecules, proteins, peptides, and nucleic acids. The unique structure of cubosomes also offers stability and controlled release benefits. The lipid bilayers provide a protective barrier, shielding the encapsulated drugs from degradation and improving their stability. Moreover, the cubic lattice arrangement enables the modulation of drug release kinetics by varying the lipid composition and surface modifications. This allows for the development of sustained or triggered drug release systems, enhancing therapeutic efficacy and reducing side effects. Furthermore, cubosomes can be easily modified with targeting ligands or surface modifications to achieve site-specific drug delivery, enhancing therapeutic selectivity and reducing off-target effects. In conclusion, cubosomes offer a versatile and promising platform for the delivery of therapeutic agents. In this manuscript, we will highlight some of these applications.
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