鸦片消耗与动脉粥样硬化和过度炎症状态的风险增加有关,这被认为是冠状动脉扩张症(CAE)发展的促成因素。我们旨在确定鸦片消费是否是CAE的独立危险因素。本研究旨在探讨鸦片消费与CAE的关系。
在这项倾向得分匹配的研究中,我们纳入了2004年9月至2017年3月在德黑兰心脏中心接受择期冠状动脉造影检查的患者.我们研究了患有CAE且没有冠状动脉疾病(CAD)的患者。对照组,冠状动脉造影正常的患者,在应用倾向得分匹配以匹配年龄后选择,性别,糖尿病,高血压,高脂血症,冠状动脉疾病家族史,和吸烟。
我们研究了242例纯CAE患者和968例对照患者。这些组的鸦片消费患病率没有显着差异:纯CAE组17(7.5%),对照组76(8.6%)(赔率:0.81;P=0.455)。在纯CAE患者中,鸦片消费者和非消费者之间的Markis得分没有显着差异(P=0.136)。
我们发现纯CAE患者与冠状动脉造影正常患者之间的鸦片消耗量没有显着差异。此外,纯CAE患者的鸦片消耗量与Markis评分无相关性.
Opium consumption is associated with increased risk of atherosclerosis and a hyper-inflammatory state which are suggested as contributing factors to the development of coronary artery ectasia (CAE). We aimed to determine if opium consumption is an independent risk factor of CAE. This
study aimed to explore the relationship between opium consumption and CAE.
In this propensity score-matched
study, we enrolled patients who underwent elective coronary angiography between September 2004 and March 2017 in Tehran Heart Center. We studied patients with CAE and without coronary artery disease (CAD) as cases. The control group, patients with normal coronary angiograms, were selected after applying the propensity score matching to match for age, sex, diabetes mellitus, hypertension, hyperlipidemia, family history of coronary artery disease, and cigarette smoking.
We studied 242 patients with pure CAE and selected 968 control patients. The prevalence of opium consumption was not significantly different across these groups: 17 (7.5%) in the pure CAE group compared to 76 (8.6%) in the control group (Odds ratio: 0.81; P=0.455). Amongst the patients with pure CAE, Markis scores were not significantly different between opium consumers and non-consumers (P=0.136).
We found no significant difference regarding opium consumption between patients with pure CAE and those with normal coronary angiograms. In addition, there was no correlation between opium consumption and Markis scores in patients with pure CAE.