背景:自身免疫性水疱性皮肤病(AIBD)是一组罕见的慢性自身免疫性疾病,与眼表疾病特别是干眼病有关。本研究旨在探讨自身免疫性水疱性皮肤病患者眼表疾病与生活质量之间的关系。
方法:包括24例AIBD患者(18例天疱疮和7例类天疱疮)和25例非AIBD对照。眼表疾病指数(OSDI),眼表评估,包括裂隙灯检查,Schirmer我测试,撕碎时间,角膜荧光素染色,眼睑平行结膜褶皱,睑板腺评估,我们评估了是否存在睑粘连和角膜混浊.通过多个问卷评估生活质量,包括医疗结果研究36项简短形式问卷(SF-36),医院焦虑和抑郁量表(HADS),匹兹堡睡眠质量指数(PSQI)和健康评估问卷-残疾指数(HAQ-DI)。比较了AIBD患者和非AIBD对照组的眼表测试和生活质量。在AIBD患者中,还评估了眼表参数与生活质量之间的关联.
结果:在这项研究中,92%的AIBD患者和87.5%的年龄和性别匹配的非AIBD对照者被诊断为干眼。与非AIBD对照相比,AIBD患者的SF-36评分较低(P<0.05),OSDI较严重,Schirmer我测试,撕碎时间,角膜荧光素染色,角膜混浊的测量值(P<0.05)。OSDI,SchirmerI检验与SF-36综合得分或SF-36分量表得分相关。
结论:AIBD患者的生活质量下降,眼表疾病更严重,包括干眼,眼睑和角膜混浊。AIBD患者需要早期治疗干眼和多学科医师之间的合作。
BACKGROUND: Autoimmune blistering skin diseases (AIBD) are a group of rare chronic autoimmune diseases which are associated with ocular surface diseases especially dry eye disease. This
study is designed to investigate the relationship between ocular surface disorders and quality of life among patients with autoimmune blistering skin diseases.
METHODS: Twenty-four AIBD patients (18 pemphigus and 7 pemphigoid) and twenty-five non-AIBD controls were included. Ocular surface disease index (OSDI), ocular surface evaluation, including slit-lamp examination, Schirmer I test, tear break-up time, corneal fluorescein staining, lid-parallel conjunctival folds, meibomian gland evaluation, presence of symblepharon and corneal opacity were assessed. Life quality was evaluated by multiple questionnaires, including Medical Outcomes
Study 36-Item Short Form Questionnaire (SF-36), Hospital Anxiety and Depression Scale (HADS), Pittsburgh Sleep Quality Index (PSQI) and Health Assessment Questionnaire-Disability Index (HAQ-DI). Ocular surface tests and quality of life were compared between AIBD patients and non-AIBD controls. In the AIBD patients, the associations between ocular surface parameters and quality of life were also evaluated.
RESULTS: 92% of AIBD patients and 87.5% of age- and sex-matched non-AIBD controls were diagnosed with dry eye in this
study. Compared with non-AIBD controls, AIBD patients reported lower SF-36 scores (P < 0.05) and severer OSDI, Schirmer I test, tear break-up time, corneal fluorescein staining, presence of symblepharon and corneal opacity measures (P < 0.05). OSDI, Schirmer I test were correlated with SF-36 composite scores or scores on the SF-36 subscales.
CONCLUSIONS: AIBD patients experience reduced quality of life and more severe ocular surface disorders including dry eye, symblepharon and corneal opacity. Early treatments of dry eye and collaborations among multidisciplinary physicians are necessary in patients with AIBD.