■沙特食品和药物管理局(SFDA)在2018年将普瑞巴林列为受控物质;然而,目前尚不清楚这一政策变化是否影响了普瑞巴林的使用。这项研究检查了SFDA限制前后普瑞巴林处方的趋势。此外,还评估了受控镇痛药的共同处方和普瑞巴林用于批准的适应症的使用。
■对沙特阿拉伯三个医疗中心的门诊普瑞巴林处方进行了横断面研究。中断时间序列分析用于评估普瑞巴林处方随时间的变化和接受普瑞巴林的患者人数。2016年6月至2017年6月被确定为限制前期限,并以2018年7月至2019年7月为限售期后。
■在这项研究中,确定了77,760份普瑞巴林处方。限制前服用普瑞巴林的9,076名患者,处方为16,875张,与7123例患者和19,484例限制后处方相比。普瑞巴林使用者总数在限售后减少21.5%,处方增加了15.5%。限制前后普瑞巴林处方的月趋势没有显着变化。然而,在使用普瑞巴林的患者中,曲马多和对乙酰氨基酚/可待因处方在限制期增加了21%和16.1%,分别。
■实施SFDA强制的处方限制后,普瑞巴林的使用减少。与此同时,在实施后阶段,麻醉品的使用有所增加。
UNASSIGNED: The Saudi Food and Drug Authority (SFDA) classified pregabalin as a controlled substance in 2018; however, whether this policy change has affected pregabalin use is unclear. This
study examined the trends in pregabalin prescriptions before and after the SFDA restriction. In addition, the co-prescription of controlled analgesics and the use of pregabalin for approved indications were also evaluated.
UNASSIGNED: A cross-sectional
study was conducted on outpatient pregabalin prescriptions from three healthcare centers in Saudi Arabia. Interrupted time series analysis was used to assess changes over time in pregabalin prescriptions and the number of patients receiving pregabalin. June 2016 to June 2017 was identified as the pre-restriction period, and July 2018 to July 2019 as the post-restriction period.
UNASSIGNED: In this
study, 77,760 pregabalin prescriptions were identified. There were 9,076 patients on pregabalin in the pre-restriction period with 16,875 prescriptions, compared with 7,123 patients and 19,484 prescriptions post-restriction. The total number of pregabalin users decreased by 21.5% post-restriction, and prescriptions increased by 15.5%. There was no significant change in the monthly trends in pregabalin prescriptions before and after the restriction. However, the of tramadol and acetaminophen/codeine prescriptions in patients who were using pregabalin increased in the post-restriction period by 21% and 16.1%, respectively.
UNASSIGNED: Pregabalin use was reduced after the SFDA-enforced prescription restriction was implemented. This was accompanied by increased narcotics use in the post-implementation phase.