这项研究的目的是探索非风湿性钙化性主动脉瓣疾病（nrCAVD）的最新变化趋势，并揭示可能的改善。我们分析了患病率的年龄标准化率(ASR)，发病率,残疾调整寿命年(DALYs)，使用2019年全球疾病负担（GBD）研究的数据，从1990年到2019年nrCAVD的死亡率趋势。用皮尔逊相关系数分析ASR与社会人口统计学指数(SDI)的关系。通过分解和前沿分析，揭示了影响因素的贡献比例和可以实现改进的区域。2019年，全球有940万人（95％的不确定性区间（UI）：8.07至1089万人）患有nrCAVD。从1990年到2019年，nrCAVD的患病率增加了155.47％（95％IU：141.66％至171.7％），在中间SDI区域观察到最大的增长(821.11%，95%UI：709.87%至944.23%）。全球范围内,nrCAVD的死亡率没有显著变化(0.37%，95%UI：-8.85%至7.99%）。全球DALY下降10.97%（95%UI：-17.94%至-3.46%）。在15-49岁的人群中，高收缩压的人群归因分数（PAF）增加，而在50岁以上的人群中略有下降。人口增长是全球DALY增加的主要因素（74.73％），而衰老是高SDI地区的驱动力(80.27%)。荷兰,芬兰,卢森堡,德国,挪威可以利用他们的社会人口资源降低nrCAVD的DALY率。根据这些结果,我们发现，从1990年到2019年，高SDI和中高SDI地区的nrCAVD负担显着增加。自2013年以来，nrCAVD导致的死亡率呈下降趋势，这可能是由于经导管主动脉瓣置换术取得了重大进展。一些国家可能会利用其社会人口资源减轻nrCAVD的负担。
The aim of this
study was to explore the most updated changing trends of non-rheumatic calcific aortic valve disease (nrCAVD) and reveal possible improvements. We analyzed the age-standardized rates (ASRs) of prevalence, incidence, disability-adjusted life-years (DALYs), and mortality trends of nrCAVD from 1990 to 2019 using data from the Global Burden of Disease (GBD)
study 2019. The relations between ASRs and socio-demographic index (SDI) were analyzed with Pearson\'s correlation coefficients. Decomposition and frontier analysis were employed to reveal the contribution proportion of influence factors and regions where improvement can be achieved. In 2019, there were 9.40 million (95% uncertainty interval (UI): 8.07 to 10.89 million) individuals with nrCAVD globally. From 1990 to 2019, the prevalence rate of nrCAVD increased by 155.47% (95% IU: 141.66% to 171.7%), with the largest increase observed in the middle SDI region (821.11%, 95% UI: 709.87% to 944.23%). Globally, there were no significant changes in the mortality rate of nrCAVD (0.37%, 95% UI: -8.85% to 7.99%). The global DALYs decreased by 10.97% (95% UI: -17.94% to -3.46%). The population attributable fraction (PAF) of high systolic blood pressure increased in the population aged 15-49 years, while it declined slightly in population aged 50+ years. Population growth was the main contributing factor to the increased DALYs across the globe (74.73%), while aging was the driving force in the high-SDI region (80.27%). The Netherlands, Finland, Luxembourg, Germany, and Norway could reduce DALY rates of nrCAVD using their socio-demographic resources. According to these results, we revealed that the burden of nrCAVD increased markedly from 1990 to 2019 in high-SDI and high-middle-SDI regions. There was a downward trend in the mortality due to nrCAVD since 2013, which is possibly owing to profound advances in transcatheter aortic valve replacement. Some countries may reduce burdens of nrCAVD using their socio-demographic resources.
