背景:澳大利亚足球是一项充满活力的团队运动,需要许多运动特质才能成功。由于这种特征的组合,以及技术技能和身体素质,有许多类型的伤害可能发生。受伤不仅是个人球员的障碍,而是整个团队。许多力量和训练人员努力减少对球员的伤害,以实现团队成功。
目的:研究选定的多态性是否与澳大利亚优秀男性足球运动员的损伤发生有关。
方法:使用从46名精英男性球员获得的DNA,我们调查了多个基因(ACTN3,CCL2,COL1A1,COL5A1,COL12A1,EMILIN1,IGF2,NOGGIN,SMAD6)具有损伤发生率,严重程度,类型(接触和非接触),和组织(肌肉,骨头,肌腱,韧带)在一支澳大利亚足球联赛球队中超过7年。
结果:在NOGGIN中的rs1372857变体(p=0.023)与总肌肉损伤数量之间观察到显着关联,GG基因型的携带者估计受伤次数较高,适度,或合并中度和高度严重程度的总肌肉损伤。COL5A1rs12722TT基因型与总肌肉损伤的数量也有显著关联(p=0.028)。COL5A1变体也与接触性骨损伤有显著关联(p=0.030),与中度额定伤害有显著关联。IGF2rs3213221-CC变体与每场比赛较高的接触性肌腱损伤估计数量显着相关(p=0.028),而每场比赛总韧带(p=0.019)和非接触韧带(p=0.002)损伤的估计数量较高与COL1A1rs1800012-TT基因型的携带显着相关。
结论:我们的初步研究是首次研究澳大利亚足球中遗传变异与损伤之间的关联。NOGGINrs1372857-GG,COL5A1rs12722-TT,IGF2rs3213221-CC,和COL1A1rs1800012-TT基因型与肌肉,骨头-,不同严重程度的肌腱和韧带相关损伤。为了进一步提高我们对这些的认识,和其他,遗传变异与损伤的关联,使用更多参与者和更多候选基因的全竞争AFL研究至关重要.
BACKGROUND: Australian Football is a dynamic team sport that requires many athletic traits to succeed. Due to this combination of traits, as well as technical skill and physicality, there are many types of injuries that could occur. Injuries are not only a hindrance to the individual player, but to the team as a whole. Many strength and conditioning personnel strive to minimise injuries to players to accomplish team success.
OBJECTIVE: To investigate whether selected polymorphisms have an association with injury occurrence in elite male Australian Football players.
METHODS: Using DNA obtained from 46 elite male players, we investigated the associations of injury-related polymorphisms across multiple genes (ACTN3, CCL2, COL1A1, COL5A1, COL12A1, EMILIN1, IGF2, NOGGIN, SMAD6) with injury incidence, severity, type (
contact and non-
contact), and tissue (muscle, bone, tendon, ligament) over 7 years in one Australian Football League team.
RESULTS: A significant association was observed between the rs1372857 variant in NOGGIN (p = 0.023) and the number of total muscle injuries, with carriers of the GG genotype having a higher estimated number of injuries, and moderate, or combined moderate and high severity rated total muscle injuries. The COL5A1 rs12722TT genotype also had a significant association (p = 0.028) with the number of total muscle injuries. The COL5A1 variant also had a significant association with
contact bone injuries (p = 0.030), with a significant association being found with moderate rated injuries. The IGF2 rs3213221-CC variant was significantly associated with a higher estimated number of
contact tendon injuries per game (p = 0.028), while a higher estimated number of total ligament (p = 0.019) and non-contact ligament (p = 0.002) injuries per game were significantly associated with carriage of the COL1A1 rs1800012-TT genotype.
CONCLUSIONS: Our preliminary
study is the first to examine associations between genetic variants and injury in Australian Football. NOGGIN rs1372857-GG, COL5A1 rs12722-TT, IGF2 rs3213221-CC, and COL1A1 rs1800012-TT genotypes held various associations with muscle-, bone-, tendon- and ligament-related injuries of differing severities. To further increase our understanding of these, and other, genetic variant associations with injury, competition-wide AFL studies that use more players and a larger array of gene candidates is essential.