背景:系统评价通常认为,由于报告结果的异质性,结果的可信度较低。核心结果集(COS)是针对特定健康领域的商定的标准化结果集合。COS中包含的结果将在临床试验以及系统评价中进行测量和总结,以抵消这种异质性。
目的:目的是确定,汇编和评估最终和正在进行的研究,这些研究优先考虑妊娠和分娩领域的结局。
方法:所有使用共识方法优先考虑妊娠和分娩结局的研究,包括德尔福调查或共识会议。搜索在OvidMEDLINE进行,EMBASE,PsycINFO,学术搜索精英,CINAHL,截至2021年6月的Socindex和COMET数据库。对于所有符合纳入标准的研究,关于结果和人口的信息,方法,并提取了设置。此外,最终研究的报告使用核心结果集-STAndards报告的修订版进行评估.
结果:总计,27项最终研究和42项正在进行的研究被评估为相关研究,并被纳入。在最终的研究中,纳入COS的结局数量为6~51个,中位数为13个.大多数确定的COS,无论是最终还是正在进行中,与怀孕期间的身体并发症有关。
结论:与妊娠和分娩相关的核心结果集研究越来越多。尽管有几项最终的研究遵循了拟议的报告,仍然有一些项目并不总是清楚地报告。此外,几个确定的COS包含大量(n>20)结果,可能会阻碍实施的东西。因此,有必要考虑COS中可能包含的结果数量,以使其对未来的研究处于最佳状态.
BACKGROUND: Systematic reviews often conclude low confidence in the results due to heterogeneity in the reported outcomes. A Core Outcome Set (COS) is an agreed standardised collection of outcomes for a specific area of health. The outcomes included in a COS are to be measured and summarized in clinical trials as well as systematic reviews to counteract this heterogeneity.
OBJECTIVE: The aim is to identify, compile and assess final and ongoing studies that are prioritizing outcomes in the area of pregnancy and childbirth.
METHODS: All studies which prioritized outcomes related to pregnancy and childbirth using consensus method, including Delphi surveys or consensus meetings were included. Searches were conducted in Ovid MEDLINE, EMBASE, PsycINFO, Academic Search Elite, CINAHL, SocINDEX and COMET databases up to June 2021. For all studies fulfilling the inclusion criteria, information regarding outcomes as well as population, method, and setting was extracted. In addition, reporting in the finalized studies was assessed using a modified version of the Core Outcome Set-STAndards for Reporting.
RESULTS: In total, 27 finalized studies and 42 ongoing studies were assessed as relevant and were included. In the finalized studies, the number of outcomes included in the COS ranged from 6 to 51 with a median of 13 outcomes. The majority of the identified COS, both finalized as well as ongoing, were relating to physical complications during pregnancy.
CONCLUSIONS: There is a growing number of Core Outcome Set studies related to pregnancy and childbirth. Although several of the finalized studies follow the proposed reporting, there are still some items that are not always clearly reported. Additionally, several of the identified COS contained a large number (n > 20) outcomes, something that possibly could hinder implementation. Therefore, there is a need to consider the number of outcomes which may be included in a COS to render it optimal for future research.