背景高血压是心血管疾病和死亡的主要危险因素。高血压的适当治疗对于降低死亡率是必要的。基于处方的研究是检查医生不合理处方实践的最有影响力和最有用的方法之一。本研究旨在调查医生的抗高血压处方及其对治疗指南的依从性。以及沙特阿拉伯王国一家综合医院的血压(BP)控制率。方法回顾性,横断面研究于2020年2月至2021年6月在一家门诊部进行.包括根据2020年国际高血压协会指南诊断为高血压的患者和接受抗高血压药物的患者。研究数据包括处方,病人的年龄,高血压的持续时间,合并症,BP,药物治疗类型,和抗高血压类。总体结果,血管紧张素转换酶抑制剂/血管紧张素II受体阻滞剂(67.1%)是处方最多的药物,其次是二氢吡啶-钙通道阻滞剂(62.6%),利尿剂(26.1%),和β受体阻滞剂(10.1%)。合并和2期高血压患者主要接受联合治疗(51.6%),而不是单一治疗(48.4%)。该研究揭示了83.5%的处方对治疗指南的依从性。然而,在单药治疗中遇到了非依从性,综合疗法,和接受老年治疗的患者组。观察到血压控制率为66.4%(所有病例的目标血压<140/90mmHg)和39.3%(合并症患者的目标血压<130/80mmHg)。此外,血压控制率与处方依从性显著相关(χ2=71.316;p<0.001)。结论处方依从性和血压控制率与其他已发表的高血压研究一致。然而,在合理药物利用和血压控制率方面存在相当大的改进空间,特别是高危患者。因此,在沙特人群中,临床医生必须遵循治疗指南,以实现BP目标并减少心血管事件.
Background Hypertension is the leading risk factor for cardiovascular disease and death. Appropriate treatment of hypertension is necessary to reduce mortality. A prescription-based study is one of the most influential and helpful methods to examine physicians\' irrational prescribing practices. This study was designed to investigate the antihypertensive prescription of physicians and their adherence to the treatment
guidelines, as well as the blood pressure (BP) control rate in a general hospital in the Kingdom of Saudi Arabia. Methodology A retrospective, cross-sectional study was conducted between February 2020 and June 2021 in an outpatient department. Patients diagnosed with hypertension as per the 2020 International Society of Hypertension
guidelines and those who received antihypertensive drugs were included. Study data included prescriptions, patient\'s age, duration of hypertension, comorbidities, BP, drug therapy type, and antihypertensive class. Results Overall, angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers (67.1%) were the most prescribed agents, followed by dihydropyridine-calcium channel blockers (62.6%), diuretics (26.1%), and β-blockers (10.1%). Comorbid and stage 2 hypertensive patients mainly received combination therapy (51.6%) rather than monotherapy (48.4%). The study revealed an 83.5% prescription adherence to the treatment
guidelines. However, non-adherence was encountered in monotherapy, polytherapy, and elderly-treated patient groups. A 66.4% (at target BP in all cases <140/90 mmHg) and 39.3% (at target BP in comorbid patients <130/80 mmHg) rate of BP control was observed. Furthermore, the rate of BP control was significantly associated with prescription adherence (χ2 = 71.316; p < 0.001). Conclusions The degree of prescription adherence and rate of BP control were found to be compatible with other published hypertension studies. However, considerable scope exists for improvement in rational drug utilization and rate of BP control, particularly in high-risk patients. Therefore, treatment
guidelines must be followed by clinicians to achieve BP goals and reduce cardiovascular events among the Saudi population.