描述C3肾小球肾炎(C3GN)是一种罕见的疾病,属于C3肾小球病(C3G)的范畴。C3G的经典表现包括急性肾功能衰竭,蛋白尿,还有血尿.在某些情况下,肾外表现可包括眼玻璃疣。直到最近的报道,尚未报道C3G表现为肺部症状。在这份报告中,我们描述了一个最初出现咯血和急性肾功能衰竭的病人,最终导致肺肾综合征的诊断。肾活检显示C3GN。患者的症状用脉冲剂量类固醇改善,血浆置换和霉酚酸酯。出现肺部症状的C3G很少见。需要进一步的研究来了解肺实质中补体沉积的机制,并确定治疗这些患者的标准疗法。临床医生应该意识到C3GN可能引起的潜在肺部表现。
Description C3 glomerulonephritis (C3GN) is a rare disease that falls under the umbrella of C3 glomerulopathy (C3G). Classic manifestations of C3G include acute renal failure, proteinuria, and hematuria. In some cases, extrarenal manifestations can include ocular drusen. Until recent
reports, C3G manifesting with pulmonary symptoms has not been reported. In this report, we describe a patient that initially presented with hemoptysis and acute renal failure, eventually leading to a diagnosis of pulmonary renal syndrome. Renal biopsy showed C3GN. The patient\'s symptoms improved with pulse dose steroids, plasmapheresis and mycophenolate mofetil. C3G presenting with pulmonary symptoms is rare. Further research is needed to understand the mechanism of complement deposition in the lung parenchyma and to determine a standard therapy to treat these patients. Clinicians should be aware of the potential pulmonary manifestations that can be caused by C3GN.