Postbiotics,作为新兴产品,被添加到婴儿配方奶粉中,但其安全性和有效性尚不清楚.为了澄清这个问题,我们写了这个荟萃分析。我们搜索了PubMed,Embase,WebofScienceandProQuest从成立到2023年2月。该审查已在PROSPERO数据库(CRD4202235405)上注册。比较了含和不含益生菌的婴儿配方食品的效果,和严重不良事件(SAE)的发生率,消化症状,粪便分泌免疫球蛋白A(SIgA)的浓度,并对生长发育指标进行了分析。纳入了9项随机对照试验,共2065名参与者。发现在婴儿配方奶粉中添加postbiotics会增加粪便SIgA的浓度(P<0.05),证据的确定性非常低,在不显著影响SAE发生率的情况下,婴儿绞痛,胀气,腹泻,呕吐,腹痛和胃肠道疾病,每天的体重增加,体长总增益和每日头围增益(均P>0.05)。在配方奶粉中添加postbiotics对婴儿是安全的,这不会增加SAE的发病率,婴儿绞痛,胀气,腹泻,呕吐,腹痛,和胃肠道疾病,并能增加粪便SIgA的浓度。影响:我们的研究提供了证据,表明在婴儿配方奶粉中添加益生菌是安全的,但不是有效的。这是对postbiotics的首次系统评价和荟萃分析。本研究为postbiotics的安全性提供了有力的证据,为相关临床试验奠定了基础。
Postbiotics, as emerging products, were added to infant formula, but their safety and efficacy are unclear. To clarify this issue, we wrote this meta-analysis. We searched PubMed, Embase, Web of Science and ProQuest from its establishment to February 2023. The
review was registered on PROSPERO database (CRD42022352405). The effects of infant formula with and without postbiotics were compared, and the incidence of serious adverse events (SAEs), digestive symptoms, concentration of stool secretory immunoglobulin A (SIgA), and growth and development indexes were analyzed. Nine randomized controlled trials with 2065 participants were included. The addition of postbiotics to infant formula was found to increase the concentration of stool SIgA (P < 0.05) with very low certainty of evidence, without significantly impacting the incidence of SAEs, infantile
colic, flatulence, diarrhea, vomiting, abdominal pain and gastrointestinal disorders, the daily weight gain, the total gain in body length and the daily head circumference gain (all P > 0.05). Adding postbiotics to the formula is safe for infants, which would not increase the incidence of SAEs, infantile
colic, flatulence, diarrhea, vomiting, abdominal pain, and gastrointestinal disorders, and could increase the concentration of stool SIgA. IMPACT: Our study provides evidence that the addition of postbiotics to infant formula is safe but not effective. This is the first systematic
review and meta-analysis of postbiotics. This study provides strong evidence for the safety of postbiotics and lays a foundation for related clinical trials.