背景:这篇综述探讨了认知储备(CR)与大脑衰老的关系的概念,特别是在痴呆症及其早期阶段。CR是指尽管大脑老化,个体维持或恢复认知功能的能力,损坏,或疾病。各种因素,包括教育,职业复杂性,休闲活动,和遗传学被认为会影响CR。
方法:我们在CR的背景下修订了文献。共鉴定出842篇文章,然后我们根据标题和摘要严格评估文章的相关性,采用系统的方法来消除与我们的研究目标不符的研究。
结果:我们以一种关键的方式评估-通常用于定义和测量CR的方法,包括社会行为代理,神经影像学,以及电生理和遗传测量。讨论了这些措施的挑战和局限性,强调需要更有针对性的研究,以增进理解,定义,和CR的测量。
结论:该综述强调了在正常和病理性脑老化的背景下理解CR的重要性,并强调了进一步研究以确定和增强这种保护因素对健康和神经系统受损的老年人认知保护的重要性。
结论:这篇综述探讨了认知储备在大脑衰老中的概念,在痴呆症及其早期阶段的背景下。我们已经评估了通常用于定义和测量认知储备的方法。社会行为代理,神经影像学,并讨论了电生理和遗传措施。该综述强调了进一步研究以识别和增强这种保护因素对认知保护的重要性。
This
review examines the concept of cognitive reserve (CR) in relation to brain aging, particularly in the context of dementia and its early stages. CR refers to an individual\'s ability to maintain or regain cognitive function despite brain aging, damage, or disease. Various factors, including education, occupation complexity, leisure activities, and genetics are believed to influence CR.
We revised the literature in the context of CR. A total of 842 articles were identified, then we rigorously assessed the relevance of articles based on titles and abstracts, employing a systematic approach to eliminate studies that did not align with our research objectives.
We evaluate-also in a critical way-the methods commonly used to define and measure CR, including sociobehavioral proxies, neuroimaging, and electrophysiological and genetic measures. The challenges and limitations of these measures are discussed, emphasizing the need for more targeted research to improve the understanding, definition, and measurement of CR.
The
review underscores the significance of comprehending CR in the context of both normal and pathological brain aging and emphasizes the importance of further research to identify and enhance this protective factor for cognitive preservation in both healthy and neurologically impaired older individuals.
This
review examines the concept of cognitive reserve in brain aging, in the context of dementia and its early stages. We have evaluated the methods commonly used to define and measure cognitive reserve. Sociobehavioral proxies, neuroimaging, and electrophysiological and genetic measures are discussed. The
review emphasizes the importance of further research to identify and enhance this protective factor for cognitive preservation.